phosphoric acid 2-difluoromethyl-4-{3-[2-(pyridin-2-yldisulfanyl)-ethylcarbamoyl]-propionylamino}-phenyl ester diethyl ester

Base Information

• Chemical Name: phosphoric acid 2-difluoromethyl-4-{3-[2-(pyridin-2-yldisulfanyl)-ethylcarbamoyl]-propionylamino}-phenyl ester diethyl ester
• CAS No.: 429692-38-6
• Molecular Formula: C₂₂H₂₈F₂N₃O₆PS₂
• Molecular Weight: 563.583
• Mol file: 429692-38-6.mol

Synonyms:

Chemical Property of phosphoric acid 2-difluoromethyl-4-{3-[2-(pyridin-2-yldisulfanyl)-ethylcarbamoyl]-propionylamino}-phenyl ester diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phosphoric acid 2-difluoromethyl-4-{3-[2-(pyridin-2-yldisulfanyl)-ethylcarbamoyl]-propionylamino}-phenyl ester diethyl ester

There total 5 articles about phosphoric acid 2-difluoromethyl-4-{3-[2-(pyridin-2-yldisulfanyl)-ethylcarbamoyl]-propionylamino}-phenyl ester diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Nitrosalicylaldehyde (97-51-8) → phosphoric acid 2-difluoromethyl-4-{3-[2-(pyridin-2-yldisulfanyl)-ethylcarbamoyl]-propionylamino}-phenyl ester diethyl ester (429692-38-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / Et₃N / CH₂Cl₂

2: Et₂NSF₃ / 0.42 h / 0 °C

3: H₂ / Pd/C

4: CH₂Cl₂

5: N-ethyl-N'-dimethylaminopropylcarbodiimide

With diethylamino-sulfur trifluoride; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In dichloromethane;

DOI:10.1002/1521-3773(20020301)41:5<775::AID-ANIE775>3.0.CO;2-F

Reference yield:

phosphoric acid diethyl ester 2-formyl-4-nitro-phenyl ester (150196-45-5) → phosphoric acid 2-difluoromethyl-4-{3-[2-(pyridin-2-yldisulfanyl)-ethylcarbamoyl]-propionylamino}-phenyl ester diethyl ester (429692-38-6)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₂NSF₃ / 0.42 h / 0 °C

2: H₂ / Pd/C

3: CH₂Cl₂

4: N-ethyl-N'-dimethylaminopropylcarbodiimide

With diethylamino-sulfur trifluoride; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In dichloromethane;

DOI:10.1002/1521-3773(20020301)41:5<775::AID-ANIE775>3.0.CO;2-F

Reference yield:

phosphoric acid 2-difluoromethyl-4-nitro-phenyl ester diethyl ester (429692-36-4) → phosphoric acid 2-difluoromethyl-4-{3-[2-(pyridin-2-yldisulfanyl)-ethylcarbamoyl]-propionylamino}-phenyl ester diethyl ester (429692-38-6)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Pd/C

2: CH₂Cl₂

3: N-ethyl-N'-dimethylaminopropylcarbodiimide

With hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In dichloromethane;

DOI:10.1002/1521-3773(20020301)41:5<775::AID-ANIE775>3.0.CO;2-F

upstream raw materials:

2-(2-(2-pyridinyl)disulfanyl)ethylamine

N-[4-(diethoxy-phosphoryloxy)-3-difluoromethyl-phenyl]-succinamic acid

5-Nitrosalicylaldehyde

phosphoric acid diethyl ester 2-formyl-4-nitro-phenyl ester