Technology Process of 3-benzyloxy-5-(4-fluorobenzylcarbamoyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid
There total 25 articles about 3-benzyloxy-5-(4-fluorobenzylcarbamoyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium chlorite; aminosulfonic acid;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 1h;
- Guidance literature:
-
With
sodium chlorite; aminosulfonic acid;
In
tetrahydrofuran; water;
at 20 ℃;
for 1h;
Inert atmosphere;
Cooling with ice;
DOI:10.1021/jm301550c
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: sodium hydroxide; ammonia / ethanol; water / 1 h / 90 °C
2.1: N-Bromosuccinimide / acetonitrile / 1.5 h / 20 °C
3.1: triethylamine / palladium diacetate; 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 18.5 h / 20 - 80 °C
4.1: 0.67 h / 130 °C
5.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 1.5 h / 0 - 20 °C
6.1: 0.37 h / 130 °C
7.1: methanol; sodium hydroxide; water / 0.67 h / 0 - 50 °C
7.2: 0 °C
8.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1.5 h / 80 °C
9.1: manganese(IV) oxide / chloroform / 1.33 h / 20 - 60 °C
10.1: sodium chlorite; aminosulfonic acid / tetrahydrofuran / 1 h / 0 - 20 °C
With
methanol; manganese(IV) oxide; sodium hydroxide; sodium chlorite; N-Bromosuccinimide; aminosulfonic acid; ammonia; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid;
palladium diacetate; 1,3-bis-(diphenylphosphino)propane;
In
tetrahydrofuran; ethanol; chloroform; water; N,N-dimethyl-formamide; acetonitrile;
