C₂₅H₁₉F₆IO₄

Base Information

• Chemical Name: C₂₅H₁₉F₆IO₄
• CAS No.: 264278-18-4
• Molecular Formula: C₂₅H₁₉F₆IO₄
• Molecular Weight: 624.318
• Mol file: 264278-18-4.mol

Synonyms:

Chemical Property of C₂₅H₁₉F₆IO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₁₉F₆IO₄

There total 9 articles about C₂₅H₁₉F₆IO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

silver trifluoroacetate (2966-50-9) + C21H19Cl2I (264278-14-0) → C25H19F6IO4 (264278-18-4)

Guidance literature:

In acetonitrile;

DOI:10.1007/BF02252167

Reference yield:

para-bromotoluene (106-38-7) → C25H19F6IO4 (264278-18-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: magnesium / diethyl ether

1.2: diethyl ether / 24 h / 0 - 20 °C

1.3: 71 percent / NH₄Cl / diethyl ether; H₂O

2.1: 17.9 g / Zn / acetic acid; H₂O / 2 h / 100 °C

3.1: 17.22 g / KOH / ethane-1,2-diol / 10 h / Heating

4.1: H₂SO₄; NaNO₂ / acetic acid

4.2: 15.53 g / CuI; KI; HI / diethyl ether; acetic acid

5.1: 6.1 g / Cl₂ / CCl₄; petroleum ether / 5 - 10 °C

6.1: 73 percent / acetonitrile

With potassium hydroxide; sulfuric acid; chlorine; magnesium; zinc; sodium nitrite; In tetrachloromethane; diethyl ether; water; ethylene glycol; acetic acid; acetonitrile; Petroleum ether; 1.1: Metallation / 1.2: Grignard reaction / 1.3: Hydrolysis / 2.1: Reduction / 3.1: Deacetylation / 4.1: Diazotization / 4.2: Substitution / 5.1: Chlorination / 6.1: Substitution;

DOI:10.1007/BF02252167

Reference yield:

2-methyl-4-oxo-3,1-benzoxazine (525-76-8) → C25H19F6IO4 (264278-18-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: magnesium / diethyl ether

1.2: diethyl ether / 24 h / 0 - 20 °C

1.3: 71 percent / NH₄Cl / diethyl ether; H₂O

2.1: 17.9 g / Zn / acetic acid; H₂O / 2 h / 100 °C

3.1: 17.22 g / KOH / ethane-1,2-diol / 10 h / Heating

4.1: H₂SO₄; NaNO₂ / acetic acid

4.2: 15.53 g / CuI; KI; HI / diethyl ether; acetic acid

5.1: 6.1 g / Cl₂ / CCl₄; petroleum ether / 5 - 10 °C

6.1: 73 percent / acetonitrile

With potassium hydroxide; sulfuric acid; chlorine; magnesium; zinc; sodium nitrite; In tetrachloromethane; diethyl ether; water; ethylene glycol; acetic acid; acetonitrile; Petroleum ether; 1.1: Metallation / 1.2: Grignard reaction / 1.3: Hydrolysis / 2.1: Reduction / 3.1: Deacetylation / 4.1: Diazotization / 4.2: Substitution / 5.1: Chlorination / 6.1: Substitution;

DOI:10.1007/BF02252167

upstream raw materials:

silver trifluoroacetate

C₂₁H₁₉Cl₂I

2-methyl-4-oxo-3,1-benzoxazine

para-bromotoluene

Refernces