(3R)-3-Pyrrolidineacetic acid ethyl ester

Base Information

Chemical Name:(3R)-3-Pyrrolidineacetic acid ethyl ester
CAS No.:808157-10-0
Molecular Formula:C₈H₁₅NO₂
Molecular Weight:157.213
Hs Code.:
Mol file:808157-10-0.mol

Synonyms:

Suppliers and Price of (3R)-3-Pyrrolidineacetic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 3 raw suppliers

Chemical Property of (3R)-3-Pyrrolidineacetic acid ethyl ester

Chemical Property:

Boiling Point:210.9±13.0 °C(Predicted)
PKA:10.11±0.10(Predicted)
Density:0.989±0.06 g/cm3(Predicted)

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R)-3-Pyrrolidineacetic acid ethyl ester

There total 8 articles about (3R)-3-Pyrrolidineacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1,1-dimethylethyl(3R)-3-[2-(ethyloxy)-2-oxoethyl]-1-pyrrolidinecarboxylate

: 808157-10-0
ethyl (R)-(-)-3-pyrrolidineacetate

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; ethanol; for 1h; Heating;
DOI:10.1016/j.tetasy.2004.08.036

Reference yield:

: 73178-43-5
(E)-diethyl glutaconate

: 808157-10-0
ethyl (R)-(-)-3-pyrrolidineacetate

Guidance literature:: Multi-step reaction with 8 steps

1: 84 percent / 1,1,3,3-tetramethylquanidine / 24 h / 20 °C

2: 82 percent / Porcine liver acetone powder; sodium hydroxide; phosphate buffer / 2 h / 20 °C / pH 7

3: hydrogen; Raney nickel / ethanol / 3 h / 20 °C / 760 Torr

4: 0.60 g / toluene; ethanol / Heating

5: 100 percent / trimethylchlorosilane / 20 °C

6: 90 percent / 4-dimethylaminopyridine; triethylamine / CH₂Cl₂ / 1 h / 20 °C

7: BH₃-DMS / tetrahydrofuran / -10 - 20 °C

8: 0.16 g / hydrochloric acid / ethanol; tetrahydrofuran / 1 h / Heating

With hydrogenchloride; dmap; sodium hydroxide; chloro-trimethyl-silane; phosphate buffer; dimethylsulfide borane complex; Porcine liver acetone; hydrogen; nickel; triethylamine; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; ethanol; dichloromethane; toluene; 1: Michael reaction;
DOI:10.1016/j.tetasy.2004.08.036

Reference yield:

: 717132-73-5
diethyl 3-(nitromethyl)pentanedioate

: 808157-10-0
ethyl (R)-(-)-3-pyrrolidineacetate

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / Porcine liver acetone powder; sodium hydroxide; phosphate buffer / 2 h / 20 °C / pH 7

2: hydrogen; Raney nickel / ethanol / 3 h / 20 °C / 760 Torr

3: 0.60 g / toluene; ethanol / Heating

4: 100 percent / trimethylchlorosilane / 20 °C

5: 90 percent / 4-dimethylaminopyridine; triethylamine / CH₂Cl₂ / 1 h / 20 °C

6: BH₃-DMS / tetrahydrofuran / -10 - 20 °C

7: 0.16 g / hydrochloric acid / ethanol; tetrahydrofuran / 1 h / Heating

With hydrogenchloride; dmap; sodium hydroxide; chloro-trimethyl-silane; phosphate buffer; dimethylsulfide borane complex; Porcine liver acetone; hydrogen; nickel; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1016/j.tetasy.2004.08.036