(1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-carboxamidocyclohexane

Base Information

• Chemical Name: (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-carboxamidocyclohexane
• CAS No.: 1605280-81-6
• Molecular Formula: C₂₅H₃₉NO₃
• Molecular Weight: 401.59
• Mol file: 1605280-81-6.mol

Synonyms:

Chemical Property of (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-carboxamidocyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-carboxamidocyclohexane

There total 3 articles about (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-carboxamidocyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,3R,4R)-3-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-(1,1-dimethyl-heptyl)-phenyl]-4-isopropenyl-cyclohexanecarbaldehyde (213915-75-4) → (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-carboxamidocyclohexane (1605280-81-6)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium dihydrogenphosphate / tert-butyl alcohol; water / 0.17 h / 20 °C

2: thionyl chloride / N,N-dimethyl-formamide; toluene / 2 h / 70 °C

3: ammonium hydroxide / dichloromethane; water / -5 - 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

With ammonium hydroxide; sodium dihydrogenphosphate; thionyl chloride; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

(1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-bis(tert-butyldimethylsilyloxy)phenyl]-4-isopropenyl-1-carboxylcyclohexane (1605281-26-2) → (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-carboxamidocyclohexane (1605280-81-6)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / N,N-dimethyl-formamide; toluene / 2 h / 70 °C

2: ammonium hydroxide / dichloromethane; water / -5 - 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

With ammonium hydroxide; thionyl chloride; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

C37H65ClO3Si2 → (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-carboxamidocyclohexane (1605280-81-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium hydroxide / dichloromethane; water / -5 - 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

With ammonium hydroxide; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; water;

upstream raw materials:

(1R,3R,4R)-3-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-(1,1-dimethyl-heptyl)-phenyl]-4-isopropenyl-cyclohexanecarbaldehyde

(1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-bis(tert-butyldimethylsilyloxy)phenyl]-4-isopropenyl-1-carboxylcyclohexane