(1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-bis(tert-butyldimethylsilyloxy)phenyl]-4-isopropenyl-1-carboxylcyclohexane

Base Information

• Chemical Name: (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-bis(tert-butyldimethylsilyloxy)phenyl]-4-isopropenyl-1-carboxylcyclohexane
• CAS No.: 1605281-26-2
• Molecular Formula: C₃₇H₆₆O₄Si₂
• Molecular Weight: 631.1
• Mol file: 1605281-26-2.mol

Synonyms:(1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-bis(tert-butyldimethylsilyloxy)phenyl]-4-isopropenyl-1-carboxylcyclohexane

Chemical Property of (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-bis(tert-butyldimethylsilyloxy)phenyl]-4-isopropenyl-1-carboxylcyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-bis(tert-butyldimethylsilyloxy)phenyl]-4-isopropenyl-1-carboxylcyclohexane

There total 1 articles about (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-bis(tert-butyldimethylsilyloxy)phenyl]-4-isopropenyl-1-carboxylcyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-methyl-but-2-ene (513-35-9) + (1R,3R,4R)-3-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-(1,1-dimethyl-heptyl)-phenyl]-4-isopropenyl-cyclohexanecarbaldehyde (213915-75-4) → (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-bis(tert-butyldimethylsilyloxy)phenyl]-4-isopropenyl-1-carboxylcyclohexane (1605281-26-2)

Guidance literature:

With sodium dihydrogenphosphate; In water; tert-butyl alcohol; at 20 ℃; for 0.166667h;

Reference yield: 69.0%

(1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-bis(tert-butyldimethylsilyloxy)phenyl]-4-isopropenyl-1-carboxylcyclohexane (1605281-26-2) → (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-carboxylylcyclohexane (1605280-80-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.5h;

Reference yield:

(1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-bis(tert-butyldimethylsilyloxy)phenyl]-4-isopropenyl-1-carboxylcyclohexane (1605281-26-2) → C37H67NO3Si2

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / N,N-dimethyl-formamide; toluene / 2 h / 70 °C

2: ammonium hydroxide / dichloromethane; water / -5 - 20 °C

With ammonium hydroxide; thionyl chloride; In dichloromethane; water; N,N-dimethyl-formamide; toluene;

upstream raw materials:

2-methyl-but-2-ene

(1R,3R,4R)-3-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-(1,1-dimethyl-heptyl)-phenyl]-4-isopropenyl-cyclohexanecarbaldehyde

Downstream raw materials:

(1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-carboxylylcyclohexane

(1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-carboxamidocyclohexane

(1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-methoxycarbonylcyclohexane

(1R,3R,4R)-methyl 3-(2-hydroxy-6-methoxy-4-(2-methyloctan-2-yl)phenyl)-4-(prop-1-en-2-yl)cyclohexanecarboxylate