4-amino-2-[6-chloro-3-(3,3,4,4,4-pentafluorobutyl)imidazo[1,5-a]pyridin-1-yl]-5-(4-fluorophenyl)-5-methyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Base Information

Chemical Name:4-amino-2-[6-chloro-3-(3,3,4,4,4-pentafluorobutyl)imidazo[1,5-a]pyridin-1-yl]-5-(4-fluorophenyl)-5-methyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one
CAS No.:1350853-32-5
Molecular Formula:C₂₄H₁₇ClF₆N₆O
Molecular Weight:554.882
Hs Code.:

4-amino-2-[6-chloro-3-(3,3,4,4,4-pentafluorobutyl)imidazo[1,5-a]pyridin-1-yl]-5-(4-fluorophenyl)-5-methyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

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Chemical Property of 4-amino-2-[6-chloro-3-(3,3,4,4,4-pentafluorobutyl)imidazo[1,5-a]pyridin-1-yl]-5-(4-fluorophenyl)-5-methyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

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Technology Process of 4-amino-2-[6-chloro-3-(3,3,4,4,4-pentafluorobutyl)imidazo[1,5-a]pyridin-1-yl]-5-(4-fluorophenyl)-5-methyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

There total 6 articles about 4-amino-2-[6-chloro-3-(3,3,4,4,4-pentafluorobutyl)imidazo[1,5-a]pyridin-1-yl]-5-(4-fluorophenyl)-5-methyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3637-31-8
4,4,5,5,5-pentafluoropentanoic acid

: 1350853-32-5
4-amino-2-[6-chloro-3-(3,3,4,4,4-pentafluorobutyl)imidazo[1,5-a]pyridin-1-yl]-5-(4-fluorophenyl)-5-methyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 18 - 25 °C / Inert atmosphere

2.1: trichlorophosphate / 1,2-dichloro-ethane / 18 h / Inert atmosphere; Reflux

3.1: N-iodo-succinimide / dichloromethane / 18 h / 18 - 25 °C / Inert atmosphere

4.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 18 h / 120 °C / Inert atmosphere

5.1: ammonium chloride; trimethylaluminum / toluene / 18 h / 100 °C / Inert atmosphere

5.2: 0.5 h / 18 - 25 °C / silica gel

6.1: potassium tert-butylate / tert-butyl alcohol / 0.67 h / 110 °C / Inert atmosphere; sealed tube

With N-iodo-succinimide; potassium tert-butylate; trimethylaluminum; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: 1350853-32-5
4-amino-2-[6-chloro-3-(3,3,4,4,4-pentafluorobutyl)imidazo[1,5-a]pyridin-1-yl]-5-(4-fluorophenyl)-5-methyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium permanganate monohydrate / tetraethylammonium hydrogen sulphate / water / 4.33 h / 70 °C / Inert atmosphere

1.2: pH 1

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 18 - 25 °C / Inert atmosphere

3.1: trichlorophosphate / 1,2-dichloro-ethane / 18 h / Inert atmosphere; Reflux

4.1: N-iodo-succinimide / dichloromethane / 18 h / 18 - 25 °C / Inert atmosphere

5.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 18 h / 120 °C / Inert atmosphere

6.1: ammonium chloride; trimethylaluminum / toluene / 18 h / 100 °C / Inert atmosphere

6.2: 0.5 h / 18 - 25 °C / silica gel

7.1: potassium tert-butylate / tert-butyl alcohol / 0.67 h / 110 °C / Inert atmosphere; sealed tube

With N-iodo-succinimide; sodium permanganate monohydrate; potassium tert-butylate; trimethylaluminum; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetraethylammonium hydrogen sulphate; In dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 1350855-91-2
N-[(5-chloropyridin-2-yl)methyl]-4,4.5,5.5-pentafluoropentanamide

: 1350853-32-5
4-amino-2-[6-chloro-3-(3,3,4,4,4-pentafluorobutyl)imidazo[1,5-a]pyridin-1-yl]-5-(4-fluorophenyl)-5-methyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 1,2-dichloro-ethane / 18 h / Inert atmosphere; Reflux

2.1: N-iodo-succinimide / dichloromethane / 18 h / 18 - 25 °C / Inert atmosphere

3.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 18 h / 120 °C / Inert atmosphere

4.1: ammonium chloride; trimethylaluminum / toluene / 18 h / 100 °C / Inert atmosphere

4.2: 0.5 h / 18 - 25 °C / silica gel

5.1: potassium tert-butylate / tert-butyl alcohol / 0.67 h / 110 °C / Inert atmosphere; sealed tube

With N-iodo-succinimide; potassium tert-butylate; trimethylaluminum; ammonium chloride; trichlorophosphate; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;