3637-31-8 Usage
Synthesis
4,4,5,5,5-Pentaflfluoropentanol (1.8 kg, 10.1 mol), tetraethylammonium hydrogen sulfate (18.1 g, 0.08 mole), and water (10.8 L) were added to a 50 L QVF vessel and heated with stirring to 70 °C. Sodium permanganate monohydrate (2.33 kg, 14.14 mol) was dissolved at 20 °C in water (10.8 L) and transferred to a measure vessel. Aqueous sodium permanganate was added in aliquots (approximately 10% at a time) to the stirred aqueous solution of pentaflfluoropentanol and tetraethylammonium hydrogen sulfate maintaining a temperature of 65?75 °C by the additions of permanganate. The total time taken to add the aqueous permanganate was 2 h 30 min. The reaction was stirred at 70 °C for 4 h when gas chromatography (GC) analysis showed conversion of pentaflfluoropentanol to pentaflfluoropentanoic acid to be complete. The reaction mixture was allowed to cool to ambient temperature overnight and screened through a Celite fifilter aid (500 g) to remove precipitated manganese dioxide. The isolated manganese dioxide was washed with hot water (60 °C, 18 L). The combined aqueous layers were extracted with methyl tert-butyl ether (5.4 L), and the upper organic layer was discarded. The aqueous layer was acidifified with concentrated sulfuric acid (320 mL) to pH 1. The lower organic layer which separated was retained. The aqueous layer was extracted with methyl tert-butyl ether (2 × 5.4 L), and the upper organic layers were combined with the initial, lower organic layer. The combined organic layers were washed with water (5.4 L) and dried with anhydrous sodium sulfate. The organic solvent was removed in vacuo at 50 °C and the residue distilled to give the acid as a pale pink, low-melting solid (1.49 kg, 77%). Reference: Mahmood, A.; Robinson, G. E.; Powell, L. Org. Proc. Res. Dev. 1999, 3, 363–364.
Check Digit Verification of cas no
The CAS Registry Mumber 3637-31-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,6,3 and 7 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 3637-31:
(6*3)+(5*6)+(4*3)+(3*7)+(2*3)+(1*1)=88
88 % 10 = 8
So 3637-31-8 is a valid CAS Registry Number.
3637-31-8Relevant articles and documents
SOLUBLE GUANYLATE CYCLASE ACTIVATORS
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Page/Page column 50, (2015/06/25)
A compound of Formula I or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate (" cGMP") and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I, or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula I or a pharmaceutically acceptable salt thereof.
SOLUBLE GUANYLATE CYCLASE ACTIVATORS
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Page/Page column 70; 71, (2011/12/14)
A compound of Formula (I): or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate ("cGMP") and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I , or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the above mentioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula (I) or a pharmaceutically acceptable salt thereof
An improved oxidation of an alcohol using aqueous permanganate and phase-transfer catalyst
Mahmood, Arshed,Robinson, Graham E.,Powell, Lyn
, p. 363 - 364 (2013/09/08)
The oxidation of a primary alcohol to the corresponding carboxylic acid via permanganate and phase-transfer catalyst has been modified to circumvent impurity formation incurred during the reaction. A safe, simple, and efficient process was developed which gave the required carboxylic acid in 77% isolated yield using sodium permanganate in the presence of tetraethylammonium hydrogen sulphate.
