(4S,5S)-5-[(1R,2R)-2-Azido-1-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid methyl ester

Base Information

Chemical Name:(4S,5S)-5-[(1R,2R)-2-Azido-1-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid methyl ester
CAS No.:634916-74-8
Molecular Formula:C₂₃H₃₇N₃O₆Si
Molecular Weight:479.649
Hs Code.:

(4S,5S)-5-[(1R,2R)-2-Azido-1-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid methyl ester

Synonyms:

Suppliers and Price of (4S,5S)-5-[(1R,2R)-2-Azido-1-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4S,5S)-5-[(1R,2R)-2-Azido-1-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4S,5S)-5-[(1R,2R)-2-Azido-1-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid methyl ester

There total 6 articles about (4S,5S)-5-[(1R,2R)-2-Azido-1-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: (4S,5S)-5-((1R,2R)-2-Azido-1-benzyloxy-3-hydroxy-propyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid methyl ester

: 634916-74-8
(4S,5S)-5-[(1R,2R)-2-Azido-1-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid methyl ester

Guidance literature:: With 1H-imidazole; In dichloromethane; at 18 ℃; for 2h;
DOI:10.1039/b304063a

Reference yield:

: 127666-06-2
(3aS,7aS)-4-chloro-2,2-dimethyl-3a,7a-dihydro-1,3-benzodioxole

: 634916-74-8
(4S,5S)-5-[(1R,2R)-2-Azido-1-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: m-CPBA / CH₂Cl₂ / 11 h / 0 - 18 °C

2.1: 98 percent / LiCl; HOAc / tetrahydrofuran / 17 h / 18 °C

3.1: 91 percent / LiN₃ / dimethylformamide / 72 h / 18 °C

4.1: 100 percent / KI; NAH / tetrahydrofuran / 24 h / 0 - 18 °C

5.1: O₃; pyridine / 1 h / -78 °C

5.2: NaBH₄ / methanol / 3 h / -10 °C

6.1: imidazole / CH₂Cl₂ / 2 h / 18 °C

With pyridine; 1H-imidazole; lithium azide; sodium hydride; ozone; acetic acid; 3-chloro-benzenecarboperoxoic acid; potassium iodide; lithium chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b304063a

Reference yield:

: 139432-85-2
(1R,2R,3R,6R)-6-Azido-4-chloro-2,3-O-isopropylidenecyclohex-4-ene-1,2,3-triol

: 634916-74-8
(4S,5S)-5-[(1R,2R)-2-Azido-1-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / KI; NAH / tetrahydrofuran / 24 h / 0 - 18 °C

2.1: O₃; pyridine / 1 h / -78 °C

2.2: NaBH₄ / methanol / 3 h / -10 °C

3.1: imidazole / CH₂Cl₂ / 2 h / 18 °C

With pyridine; 1H-imidazole; sodium hydride; ozone; potassium iodide; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b304063a