[2-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-ethyl]-trimethyl-ammonium trifluoroacetate salt

Base Information

Chemical Name:[2-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-ethyl]-trimethyl-ammonium trifluoroacetate salt
CAS No.:1369390-18-0
Molecular Formula:C₂F₃O₂*C₃₃H₄₄Cl₂N₅O₅S
Molecular Weight:806.731
Hs Code.:

[2-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-ethyl]-trimethyl-ammonium trifluoroacetate salt

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Chemical Property of [2-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-ethyl]-trimethyl-ammonium trifluoroacetate salt

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Technology Process of [2-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-ethyl]-trimethyl-ammonium trifluoroacetate salt

There total 4 articles about [2-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-ethyl]-trimethyl-ammonium trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₂H₄₁Cl₂N₅O₅S

: 76-05-1
trifluoroacetic acid

: 74-88-4
methyl iodide

: 1369390-18-0
[2-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-ethyl]-trimethyl-ammonium trifluoroacetate salt

Guidance literature:: C₃₂H₄₁Cl₂N₅O₅S; methyl iodide;

trifluoroacetic acid; In acetonitrile;
DOI:10.1016/j.bmc.2012.01.036

Reference yield:

: 885699-05-8
4-(2-(dimethylamino)-2-oxoethyl)piperazine-1-carboxylic acid tert-butyl ester

: 1369390-18-0
[2-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-ethyl]-trimethyl-ammonium trifluoroacetate salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / 1,4-dioxane; methanol; dichloromethane / 4 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / Reflux

2.2: 0.5 h / 20 °C

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.01.036

Reference yield:

: C₈H₁₇N₃O*2ClH

: 1369390-18-0
[2-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-ethyl]-trimethyl-ammonium trifluoroacetate salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / Reflux

1.2: 0.5 h / 20 °C

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With lithium aluminium tetrahydride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.01.036