5-chloro-3-[(1E,3E)-3,5-dimethyl-1,3-heptadien-1-yl]-7-methyl-6,8-dioxo-2,6,7,8-tetrahydro-7-isoquinolinyl acetate

Base Information

Chemical Name:5-chloro-3-[(1E,3E)-3,5-dimethyl-1,3-heptadien-1-yl]-7-methyl-6,8-dioxo-2,6,7,8-tetrahydro-7-isoquinolinyl acetate
CAS No.:521-90-4
Molecular Formula:C₂₁H₂₄ClNO₄
Molecular Weight:389.879
Hs Code.:

Synonyms:

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Chemical Property of 5-chloro-3-[(1E,3E)-3,5-dimethyl-1,3-heptadien-1-yl]-7-methyl-6,8-dioxo-2,6,7,8-tetrahydro-7-isoquinolinyl acetate

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Technology Process of 5-chloro-3-[(1E,3E)-3,5-dimethyl-1,3-heptadien-1-yl]-7-methyl-6,8-dioxo-2,6,7,8-tetrahydro-7-isoquinolinyl acetate

There total 10 articles about 5-chloro-3-[(1E,3E)-3,5-dimethyl-1,3-heptadien-1-yl]-7-methyl-6,8-dioxo-2,6,7,8-tetrahydro-7-isoquinolinyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: (+)-Sclerotiorin

: 521-90-4,34695-81-3
sclerotioramine

Guidance literature:: With ammonium acetate; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1021/jo102448n

Reference yield:

: 521-90-4,34695-81-3
sclerotioramine

Guidance literature:: With ammonia; water; und Behandeln des Reaktionsgemisches mit verd. Salzsaeure bei 0grad;

Reference yield:

: 915789-22-9
6-ethynyl-2,4-dihydroxy-3-methylbenzaldehyde

: 521-90-4,34695-81-3
sclerotioramine

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: dmap; tetrakis(actonitrile)copper(I) hexafluorophosphate; oxygen; N-ethyl-N,N-diisopropylamine; (1R,2S,9S)-11-ethyl-7,11-diazatricyclo[7.3.1.0^2,7]tridecane / dichloromethane / 30.08 h / -78 - -10 °C

2.2: 1 h / 20 °C / pH 7.2 / aq. phosphate buffer

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4.1: N-chloro-succinimide / acetonitrile / 20 °C / Inert atmosphere

5.1: ammonium acetate / tetrahydrofuran / 20 °C / Inert atmosphere

With dmap; bis-triphenylphosphine-palladium(II) chloride; N-chloro-succinimide; copper(l) iodide; tetrakis(actonitrile)copper(I) hexafluorophosphate; ammonium acetate; oxygen; triethylamine; N-ethyl-N,N-diisopropylamine; (1R,2S,9S)-11-ethyl-7,11-diazatricyclo[7.3.1.0^2,7]tridecane; In tetrahydrofuran; dichloromethane; acetonitrile; 1.1: Sonogashira coupling;
DOI:10.1021/jo102448n