Technology Process of 7-[4-(2-butoxyethoxy)phenyl]-1-propyl-2,3,4,5-tetrahydro-1H-1-benzazepine-5-one
There total 2 articles about 7-[4-(2-butoxyethoxy)phenyl]-1-propyl-2,3,4,5-tetrahydro-1H-1-benzazepine-5-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(2-butoxyethoxy)phenyl borate; 7-bromo-1-propyl-2,3,4,5-tetrahydro-1H-1-benzazepine-5-one;
With
potassium carbonate;
In
ethanol; water; toluene;
at 20 ℃;
for 1h;
tetrakis(triphenylphosphine) palladium(0);
In
ethanol; water; toluene;
for 3h;
Heating / reflux;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 6 h / 20 °C
2.1: potassium carbonate / ethanol; water; toluene / 1 h / 20 °C
2.2: 3 h / Heating / reflux
With
sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid;
In
ethanol; water; 1,2-dichloro-ethane; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 2 h / -78 °C
1.2: 2 h / 20 °C
2.1: thionyl chloride / N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 20 °C
3.1: triethylamine / tetrahydrofuran; DMF (N,N-dimethyl-formamide) / 16 h / 0 - 20 °C
4.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C
With
hydrogenchloride; thionyl chloride; triethylamine; lithium hexamethyldisilazane;
N,N-dimethyl-formamide;
In
tetrahydrofuran; DMF (N,N-dimethyl-formamide); hexane; ethyl acetate;
