Methyl 6-pivaloyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxylate

Base Information

• Chemical Name: Methyl 6-pivaloyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxylate
• CAS No.: 1259287-87-0
• Molecular Formula: C₁₄H₁₉NO₃S
• Molecular Weight: 281.376
• Mol file: 1259287-87-0.mol

Synonyms:

Chemical Property of Methyl 6-pivaloyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 6-pivaloyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxylate

There total 5 articles about Methyl 6-pivaloyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxylate (1259287-72-3) + Trimethylacetic acid (75-98-9) → C14H19NO3S (1259287-87-0)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; at 20 - 36 ℃;

Reference yield:

3-fluoropyridine-4-carbaldehyde (40273-47-0) → C14H19NO3S (1259287-87-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 48.5 h / 0 - 20 °C

2.1: acetonitrile / 6 h / 40 °C

3.1: hydrogen; platinum(IV) oxide / methanol

4.1: carbonochloridic acid 1-chloro-ethyl ester; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 3 h / 0 - 20 °C

4.2: 3 h / Reflux

5.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 0.5 h / 20 °C

5.2: 17 h / 20 - 36 °C

With platinum(IV) oxide; carbonochloridic acid 1-chloro-ethyl ester; hydrogen; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm400385r

Reference yield:

methyl thieno[2,3-c]pyridine-2-carboxylate (870243-58-6) → C14H19NO3S (1259287-87-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: acetonitrile / 6 h / 40 °C

2.1: hydrogen; platinum(IV) oxide / methanol

3.1: carbonochloridic acid 1-chloro-ethyl ester; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 3 h / 0 - 20 °C

3.2: 3 h / Reflux

4.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 0.5 h / 20 °C

4.2: 17 h / 20 - 36 °C

With platinum(IV) oxide; carbonochloridic acid 1-chloro-ethyl ester; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; acetonitrile;

DOI:10.1021/jm400385r

upstream raw materials:

methyl 4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxylate

Trimethylacetic acid

3-fluoropyridine-4-carbaldehyde

methyl thieno[2,3-c]pyridine-2-carboxylate

Refernces

• 1、 -. "SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF". Page/Page column 100. . Retrieved 2011/01/12.