C₁₉H₂₄N₄O₆

Base Information

• Chemical Name: C₁₉H₂₄N₄O₆
• CAS No.: 1261352-29-7
• Molecular Formula: C₁₉H₂₄N₄O₆
• Molecular Weight: 404.423
• Mol file: 1261352-29-7.mol

Synonyms:

Chemical Property of C₁₉H₂₄N₄O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₂₄N₄O₆

There total 7 articles about C₁₉H₂₄N₄O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(tert-butoxycarbonyl)-3-{1-[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]-1H-1,2,3-triazol-4-yl}-L-alanine (1261352-25-3) → C19H24N4O6 (1261352-29-7)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2010.09.139

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → C19H24N4O6 (1261352-29-7)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(ll) sulfate pentahydrate; triflic azide; triethylamine / water; acetonitrile / 0.5 h / 0 °C

2: thionyl chloride / 0 - 20 °C / Inert atmosphere

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C

4: water; lithium hydroxide / tetrahydrofuran / 0 - 20 °C

With thionyl chloride; copper(ll) sulfate pentahydrate; triflic azide; water; sodium L-ascorbate; triethylamine; lithium hydroxide; In tetrahydrofuran; water; acetonitrile; tert-butyl alcohol; 3: Huisgen Cycloaddition;

DOI:10.1016/j.bmcl.2010.09.139

Reference yield:

(2S)-2-amino-4-pentynoic acid (23235-01-0) → C19H24N4O6 (1261352-29-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / 1,4-dioxane; water / 2.25 h / 0 - 20 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C

3: water; lithium hydroxide / tetrahydrofuran / 0 - 20 °C

With copper(ll) sulfate pentahydrate; water; sodium L-ascorbate; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; tert-butyl alcohol; 2: Huisgen Cycloaddition;

DOI:10.1016/j.bmcl.2010.09.139

upstream raw materials:

N-(tert-butoxycarbonyl)-3-{1-[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]-1H-1,2,3-triazol-4-yl}-L-alanine

L-phenylalanine

di-tert-butyl dicarbonate

(2S)-2-amino-4-pentynoic acid

Downstream raw materials:

3-{1-[(1S)-1-carboxy-2-phenylethyl]-1H-1,2,3-triazol-4-yl}-L-alanine hydrochloride