(1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-guanidino-butyl)-phosphonic acid diphenyl ester; hydrochloride

Base Information

Chemical Name:(1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-guanidino-butyl)-phosphonic acid diphenyl ester; hydrochloride
CAS No.:146548-70-1
Molecular Formula:C₃₃H₄₁N₆O₆P*ClH
Molecular Weight:685.16
Hs Code.:

(1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-guanidino-butyl)-phosphonic acid diphenyl ester; hydrochloride

Synonyms:

Suppliers and Price of (1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-guanidino-butyl)-phosphonic acid diphenyl ester; hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-guanidino-butyl)-phosphonic acid diphenyl ester; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-guanidino-butyl)-phosphonic acid diphenyl ester; hydrochloride

There total 3 articles about (1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-guanidino-butyl)-phosphonic acid diphenyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1184-90-3
aminoiminomethanesulfonic acid

: 146548-67-6,146610-34-6
(1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-amino-butyl)-phosphonic acid diphenyl ester; hydrochloride

: 146548-70-1,146610-36-8
(1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-guanidino-butyl)-phosphonic acid diphenyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; dmap; In ethanol; at 80 ℃;
DOI:10.1016/0040-4039(93)88011-7

Reference yield:

: 146548-65-4,146548-66-5,149194-49-0
[1-Amino-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphonic acid diphenyl ester

: 146548-70-1,146610-36-8
(1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-guanidino-butyl)-phosphonic acid diphenyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / i-BuOC(=O)Cl, 4-methylmorpholine, Et₃N / tetrahydrofuran / Ambient temperature

2: 57 percent / 1) H₂NNH₂*H₂O, 2) 10percent HCl / methanol / 80 °C

3: 88 percent / 1) DMAP, 2) 10percent HCl / ethanol / 80 °C

With 4-methyl-morpholine; hydrogenchloride; dmap; hydrazine hydrate; triethylamine; isobutyl chloroformate; In tetrahydrofuran; methanol; ethanol;
DOI:10.1016/0040-4039(93)88011-7

Reference yield:

: 146548-64-3,146610-33-5
[1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphonic acid diphenyl ester

: 146548-70-1,146610-36-8
(1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-guanidino-butyl)-phosphonic acid diphenyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / 1) H₂NNH₂*H₂O, 2) 10percent HCl / methanol / 80 °C

2: 88 percent / 1) DMAP, 2) 10percent HCl / ethanol / 80 °C

With hydrogenchloride; dmap; hydrazine hydrate; In methanol; ethanol;
DOI:10.1016/0040-4039(93)88011-7