[1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphonic acid diphenyl ester

Base Information

Chemical Name:[1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphonic acid diphenyl ester
CAS No.:146548-64-3
Molecular Formula:C₄₀H₄₁N₄O₈P
Molecular Weight:736.761
Hs Code.:

[1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphonic acid diphenyl ester

Synonyms:

Suppliers and Price of [1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphonic acid diphenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphonic acid diphenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphonic acid diphenyl ester

There total 4 articles about [1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphonic acid diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 146548-65-4,146548-66-5,149194-49-0
[1-Amino-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphonic acid diphenyl ester

: 65894-95-3
N-acetyl-R-phenylalanyl-S-proline

: 146548-64-3,146610-33-5
[1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphonic acid diphenyl ester

Guidance literature:: With 4-methyl-morpholine; triethylamine; isobutyl chloroformate; In tetrahydrofuran; Ambient temperature;
DOI:10.1016/0040-4039(93)88011-7

Reference yield:

: 85-44-9
phthalic anhydride

: 146548-64-3,146610-33-5
[1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphonic acid diphenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / toluene / Heating

2: (COCl)2, DMSO / CH₂Cl₂ / -78 °C

4: 79 percent / i-BuOC(=O)Cl, 4-methylmorpholine, Et₃N / tetrahydrofuran / Ambient temperature

With 4-methyl-morpholine; oxalyl dichloride; dimethyl sulfoxide; triethylamine; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/0040-4039(93)88011-7

Reference yield:

: 3598-60-5
4-phthalimidobutanal

: 146548-64-3,146610-33-5
[1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphonic acid diphenyl ester

Guidance literature:: Multi-step reaction with 2 steps

2: 79 percent / i-BuOC(=O)Cl, 4-methylmorpholine, Et₃N / tetrahydrofuran / Ambient temperature

With 4-methyl-morpholine; triethylamine; isobutyl chloroformate; In tetrahydrofuran;
DOI:10.1016/0040-4039(93)88011-7