3-Quinolinecarboxylic acid, 1-cyclopropyl-7-[4-[(1,1-diMethylethoxy)carbonyl]-2-Methyl-1-piperazinyl]-6-fluoro-1,4-dihydro-8-Methoxy-4-oxo-

Base Information

• Chemical Name: 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-[4-[(1,1-diMethylethoxy)carbonyl]-2-Methyl-1-piperazinyl]-6-fluoro-1,4-dihydro-8-Methoxy-4-oxo-
• CAS No.: 1219097-38-7
• Molecular Formula: C₂₄H₃₀FN₃O₆
• Molecular Weight: 475.517
• Mol file: 1219097-38-7.mol

Synonyms:

Chemical Property of 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-[4-[(1,1-diMethylethoxy)carbonyl]-2-Methyl-1-piperazinyl]-6-fluoro-1,4-dihydro-8-Methoxy-4-oxo-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

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Useful:

Technology Process of 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-[4-[(1,1-diMethylethoxy)carbonyl]-2-Methyl-1-piperazinyl]-6-fluoro-1,4-dihydro-8-Methoxy-4-oxo-

There total 7 articles about 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-[4-[(1,1-diMethylethoxy)carbonyl]-2-Methyl-1-piperazinyl]-6-fluoro-1,4-dihydro-8-Methoxy-4-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(2-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid (1029364-65-5) + 2,2-dimethylpropanoic anhydride (1538-75-6) → C24H30FN3O6 (1219097-38-7)

Guidance literature:

With triethylamine; In dichloromethane; at 25 ℃; for 0.5h; Inert atmosphere;

DOI:10.14233/ajchem.2014.15572

Reference yield:

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate (112811-71-9) → C24H30FN3O6 (1219097-38-7)

Guidance literature:

Multi-step reaction with 3 steps

1: boron trifluoride diethyl etherate / tetrahydrofuran / 48 h / Reflux; Inert atmosphere

2: dimethyl sulfoxide / 72 h / 0 - 40 °C / Inert atmosphere

3: methanol / 12 h / 60 - 65 °C / Inert atmosphere

With boron trifluoride diethyl etherate; In tetrahydrofuran; methanol; dimethyl sulfoxide;

DOI:10.14233/ajchem.2014.15572

Reference yield:

C24H29BF3N3O6 (1219495-03-0) → C24H30FN3O6 (1219097-38-7)

Guidance literature:

In methanol; at 60 - 65 ℃; for 12h; Inert atmosphere;

DOI:10.14233/ajchem.2014.15572

upstream raw materials:

di-tert-butyl dicarbonate

1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(2-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid

2,2-dimethylpropanoic anhydride

(RS)-2-methylpiperazine

Downstream raw materials:

1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(2-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid

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