2-phenyl-N-(p-tolyl)quinolin-4-amine

Base Information

• Chemical Name: 2-phenyl-N-(p-tolyl)quinolin-4-amine
• CAS No.: 1166-03-6
• Molecular Formula: C₂₂H₁₈N₂
• Molecular Weight: 310.398
• Mol file: 1166-03-6.mol

Synonyms:

Chemical Property of 2-phenyl-N-(p-tolyl)quinolin-4-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-phenyl-N-(p-tolyl)quinolin-4-amine

There total 5 articles about 2-phenyl-N-(p-tolyl)quinolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

Ethylid + 4-methylphenyl isocyanide (7175-47-5) → 2-phenyl-N-(p-tolyl)quinolin-4-amine (1166-03-6)

Guidance literature:

With silver trifluoroacetate; In toluene; at 100 ℃; for 24h; Reagent/catalyst; Solvent; Catalytic behavior; Sealed tube;

DOI:10.1021/acs.orglett.0c02835

Reference yield:

benzoyl chloride (98-88-4) → 2-phenyl-N-(p-tolyl)quinolin-4-amine (1166-03-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trialkylamine / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: thionyl chloride / 4 h / 80 °C

3.1: potassium tert-butylate / tetrahydrofuran / 2 h / Reflux

3.2: 4 h / 0 - 20 °C

4.1: silver trifluoroacetate / toluene / 24 h / 100 °C / Sealed tube

With thionyl chloride; potassium tert-butylate; silver trifluoroacetate; In tetrahydrofuran; toluene;

DOI:10.1021/acs.orglett.0c02835

Reference yield:

aniline (62-53-3) → 2-phenyl-N-(p-tolyl)quinolin-4-amine (1166-03-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trialkylamine / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: thionyl chloride / 4 h / 80 °C

3.1: potassium tert-butylate / tetrahydrofuran / 2 h / Reflux

3.2: 4 h / 0 - 20 °C

4.1: silver trifluoroacetate / toluene / 24 h / 100 °C / Sealed tube

With thionyl chloride; potassium tert-butylate; silver trifluoroacetate; In tetrahydrofuran; toluene;

DOI:10.1021/acs.orglett.0c02835

upstream raw materials:

4-methylphenyl isocyanide

benzoyl chloride

aniline

N-phenyl-benzimidoyl chloride