Methyl 4,7-dimethoxybenzo[b]thiophene-2-carboxylate

Base Information

Chemical Name:Methyl 4,7-dimethoxybenzo[b]thiophene-2-carboxylate
CAS No.:190328-69-9
Molecular Formula:C₁₂H₁₂O₄S
Molecular Weight:252.291
Hs Code.:
DSSTox Substance ID:DTXSID701224824
Nikkaji Number:J1.171.533H

Synonyms:methyl 4,7-dimethoxybenzo[b]thiophene-2-carboxylate;190328-69-9;SCHEMBL18384500;DTXSID701224824;4,7-Dimethoxybenzo[b]thiophene-2-carboxylic acid methyl ester

Suppliers and Price of Methyl 4,7-dimethoxybenzo[b]thiophene-2-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 4,7-dimethoxybenzo[b]thiophene-2-carboxylate

Chemical Property:

Vapor Pressure:0mmHg at 25°C
XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:252.04563003
Heavy Atom Count:17
Complexity:284

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C2C=C(SC2=C(C=C1)OC)C(=O)OC

Technology Process of Methyl 4,7-dimethoxybenzo[b]thiophene-2-carboxylate

There total 4 articles about Methyl 4,7-dimethoxybenzo[b]thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1206-55-9
3,6-dimethoxy-2-nitrobenzaldehyde

: 2365-48-2
Methyl thioglycolate

: 190328-69-9
methyl 4,7-dimethoxybenzo[b]thiophene-2-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 - 65 ℃; for 2h;
DOI:10.1080/00397919708006822

Reference yield: 35.0%

: 1649501-86-9
methyl (Z)-2-(2,5-dimethoxyphenylthio)-3-(dimethylamino)acrylate

: 190328-69-9
methyl 4,7-dimethoxybenzo[b]thiophene-2-carboxylate

Guidance literature:: With iodine; In 1,1,2,2-tetrachloroethane; at 120 ℃; for 12h; Inert atmosphere; Sealed tube;
DOI:10.1002/jhet.1686

Reference yield:

: 1649501-99-4
methyl 2-(2,5-dimethoxyphenylthio)acetate

: 190328-69-9
methyl 4,7-dimethoxybenzo[b]thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 12 h / 120 °C / Inert atmosphere; Sealed tube

2: iodine / 1,1,2,2-tetrachloroethane / 12 h / 120 °C / Inert atmosphere; Sealed tube

With iodine; In 1,1,2,2-tetrachloroethane;
DOI:10.1002/jhet.1686