(E)-2-Methyl-4-oxo-but-2-enoic acid {5-[(1R,2S)-3-((3R,4R)-5-acetyl-3-methoxy-4-methyl-tetrahydro-furan-2-yl)-1-methoxy-2-methyl-propyl]-3,6-dioxo-cyclohexa-1,4-dienyl}-amide

Base Information

• Chemical Name: (E)-2-Methyl-4-oxo-but-2-enoic acid {5-[(1R,2S)-3-((3R,4R)-5-acetyl-3-methoxy-4-methyl-tetrahydro-furan-2-yl)-1-methoxy-2-methyl-propyl]-3,6-dioxo-cyclohexa-1,4-dienyl}-amide
• CAS No.: 74804-36-7
• Molecular Formula: C₂₄H₃₁NO₈
• Molecular Weight: 461.512
• Mol file: 74804-36-7.mol

Synonyms:

Chemical Property of (E)-2-Methyl-4-oxo-but-2-enoic acid {5-[(1R,2S)-3-((3R,4R)-5-acetyl-3-methoxy-4-methyl-tetrahydro-furan-2-yl)-1-methoxy-2-methyl-propyl]-3,6-dioxo-cyclohexa-1,4-dienyl}-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-Methyl-4-oxo-but-2-enoic acid {5-[(1R,2S)-3-((3R,4R)-5-acetyl-3-methoxy-4-methyl-tetrahydro-furan-2-yl)-1-methoxy-2-methyl-propyl]-3,6-dioxo-cyclohexa-1,4-dienyl}-amide

There total 3 articles about (E)-2-Methyl-4-oxo-but-2-enoic acid {5-[(1R,2S)-3-((3R,4R)-5-acetyl-3-methoxy-4-methyl-tetrahydro-furan-2-yl)-1-methoxy-2-methyl-propyl]-3,6-dioxo-cyclohexa-1,4-dienyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (E)-2-Methyl-4-oxo-but-2-enoic acid {5-[(1R,2S)-3-((3R,4R)-5-acetyl-3-methoxy-4-methyl-tetrahydro-furan-2-yl)-1-methoxy-2-methyl-propyl]-3,6-dioxo-cyclohexa-1,4-dienyl}-amide (74804-36-7)

Guidance literature:

With periodic acid; 3-chloro-benzenecarboperoxoic acid; Yield given. Multistep reaction; 1.) CHCl₃, RT, 22 h, 2.) dioxane, RT, 24 h;

DOI:10.1016/S0040-4020(01)92041-1

Reference yield:

Macbecin (73341-72-7,130740-44-2) → (E)-2-Methyl-4-oxo-but-2-enoic acid {5-[3-(5-acetyl-3-methoxy-4-methyl-tetrahydro-furan-2-yl)-1-methoxy-2-methyl-propyl]-3,6-dioxo-cyclohexa-1,4-dienyl}-amide (74804-36-7)

Guidance literature:

With periodic acid; 3-chloro-benzenecarboperoxoic acid; Multistep reaction;

DOI:10.1016/S0040-4039(00)71198-1

Reference yield:

Carbamic acid (4E,6Z,10E)-20,22-dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-aza-bicyclo[16.3.1]docosa-1(22),4,6,10,18,20-hexaen-9-yl ester (73341-73-8) → (E)-2-Methyl-4-oxo-but-2-enoic acid {5-[3-(5-acetyl-3-methoxy-4-methyl-tetrahydro-furan-2-yl)-1-methoxy-2-methyl-propyl]-3,6-dioxo-cyclohexa-1,4-dienyl}-amide (74804-36-7)

Guidance literature:

Multi-step reaction with 2 steps

1: FeCl₃

2: m-chloroperbenzenic acid, HIO₄

With iron(III) chloride; periodic acid; 3-chloro-benzenecarboperoxoic acid;

DOI:10.1016/S0040-4039(00)71198-1

upstream raw materials:

Macbecin

Carbamic acid (4E,6Z,10E)-20,22-dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-aza-bicyclo[16.3.1]docosa-1⁽²²⁾,4,6,10,18,20-hexaen-9-yl ester