(R)-4-Phenyl-2-(toluene-4-sulfonylamino)-butyric acid

Base Information

Chemical Name:(R)-4-Phenyl-2-(toluene-4-sulfonylamino)-butyric acid
CAS No.:308246-16-4
Molecular Formula:C₁₇H₁₉NO₄S
Molecular Weight:333.408
Hs Code.:

Synonyms:

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Chemical Property of (R)-4-Phenyl-2-(toluene-4-sulfonylamino)-butyric acid

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Technology Process of (R)-4-Phenyl-2-(toluene-4-sulfonylamino)-butyric acid

There total 8 articles about (R)-4-Phenyl-2-(toluene-4-sulfonylamino)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 308246-12-0
(R)-N-[1'-(2-Furyl)-3'-phenylpropyl]toluene-p-sulfonamide

: 308246-16-4
(R)-4-Phenyl-2-(toluene-4-sulfonylamino)-butyric acid

: 308246-22-2
C₁₈H₁₉NO₅S

Guidance literature:: With ruthenium(IV) oxide; sodium periodate; water; In tetrachloromethane; acetonitrile; for 1h;
DOI:10.1039/b003067h

Reference yield:

: 104-53-0
3-phenyl-propionaldehyde

: 308246-16-4
(R)-4-Phenyl-2-(toluene-4-sulfonylamino)-butyric acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: 66 percent / tetrahydrofuran / 2 h / Heating

2.1: 99 percent / LiAlH₄ / diethyl ether / 1.5 h / Heating

3.1: 62 percent / H₂; aq. TFA / Pd(OH)2 / methanol / 10 h

4.1: 75 percent / Et₃N / CH₂Cl₂ / 72 h / 20 °C

5.1: NaBH₄ / ethanol / 0.5 h

5.2: 90 percent / ethanol; tetrahydrofuran / 5 h / Heating

6.1: NaIO₄; NaHCO₃ / aq. methanol / 1 h

7.1: dioxane / 1 h / Heating

7.2: 304 mg / aq. HCl / dioxane / 1 h / Heating

8.1: 68 percent / NaIO₄; RuO₂; H₂O / acetonitrile; CCl₄ / 1 h

With ruthenium(IV) oxide; sodium tetrahydroborate; sodium periodate; lithium aluminium tetrahydride; water; hydrogen; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; acetonitrile; 1.1: Condensation / 2.1: Reduction / 3.1: Hydrogenolysis / 4.1: Substitution / 5.1: Reduction / 5.2: Substitution / 6.1: Oxidation / 7.1: Elimination / 7.2: Hydrolysis / 8.1: Oxidation;
DOI:10.1039/b003067h

Reference yield:

: 182161-99-5
(5S,1'S)-N-[1'-(2-Furyl)-3'-phenylpropyl]-5-phenylmorpholin-2-one

: 308246-16-4
(R)-4-Phenyl-2-(toluene-4-sulfonylamino)-butyric acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: 99 percent / LiAlH₄ / diethyl ether / 1.5 h / Heating

2.1: 62 percent / H₂; aq. TFA / Pd(OH)2 / methanol / 10 h

3.1: 75 percent / Et₃N / CH₂Cl₂ / 72 h / 20 °C

4.1: NaBH₄ / ethanol / 0.5 h

4.2: 90 percent / ethanol; tetrahydrofuran / 5 h / Heating

5.1: NaIO₄; NaHCO₃ / aq. methanol / 1 h

6.1: dioxane / 1 h / Heating

6.2: 304 mg / aq. HCl / dioxane / 1 h / Heating

7.1: 68 percent / NaIO₄; RuO₂; H₂O / acetonitrile; CCl₄ / 1 h

With ruthenium(IV) oxide; sodium tetrahydroborate; sodium periodate; lithium aluminium tetrahydride; water; hydrogen; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; palladium dihydroxide; In 1,4-dioxane; methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; acetonitrile; 1.1: Reduction / 2.1: Hydrogenolysis / 3.1: Substitution / 4.1: Reduction / 4.2: Substitution / 5.1: Oxidation / 6.1: Elimination / 6.2: Hydrolysis / 7.1: Oxidation;
DOI:10.1039/b003067h