acetic acid 5-(5-{3-[2-(1-diphenylcarbamoyl-1H-imidazol-4-yl)-acetylamino]-propyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-methoxy-tetrahydro-furan-3-yl ester

Base Information

• Chemical Name: acetic acid 5-(5-{3-[2-(1-diphenylcarbamoyl-1H-imidazol-4-yl)-acetylamino]-propyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-methoxy-tetrahydro-furan-3-yl ester
• CAS No.: 289676-32-0
• Molecular Formula: C₃₃H₃₆N₆O₉
• Molecular Weight: 660.684

Synonyms:

Chemical Property of acetic acid 5-(5-{3-[2-(1-diphenylcarbamoyl-1H-imidazol-4-yl)-acetylamino]-propyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-methoxy-tetrahydro-furan-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of acetic acid 5-(5-{3-[2-(1-diphenylcarbamoyl-1H-imidazol-4-yl)-acetylamino]-propyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-methoxy-tetrahydro-furan-3-yl ester

There total 9 articles about acetic acid 5-(5-{3-[2-(1-diphenylcarbamoyl-1H-imidazol-4-yl)-acetylamino]-propyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-methoxy-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-O-methyluridine (2140-76-3) → acetic acid 5-(5-{3-[2-(1-diphenylcarbamoyl-1H-imidazol-4-yl)-acetylamino]-propyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-methoxy-tetrahydro-furan-3-yl ester (289676-32-0)

Guidance literature:

Multi-step reaction with 9 steps

1: 100 percent / pyridine

2: 100 percent / I₂; ceric ammonium nitrate

3: 89 percent / CuI; (Ph₃P)4P; Et₃N / dimethylformamide / 16 h

4: aq. NH₃ / 16 h / 4 °C

5: H₂ / 5 percent Pd/C / 24 h / 2068.59 Torr

6: EDC*HCl / dimethylformamide / 16 h

7: pyridine / 16 h

8: pyridine / 2 h

9: TCA / CH₂Cl₂ / 2 h

With pyridine; ammonium hydroxide; copper(l) iodide; ammonium cerium(IV) nitrate; (Ph₃P)4P; hydrogen; iodine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichloroacetic acid; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide; 1: Acetylation / 2: Iodination / 3: Substitution / 4: ammonolysis / 5: Catalytic hydrogenation / 6: Condensation / 7: tritylation / 8: Acetylation / 9: acidolysis;

DOI:10.1016/S0960-894X(00)00226-2

Reference yield:

3',5'-di-O-acetyl-2'-O-methyluridine (61671-79-2) → acetic acid 5-(5-{3-[2-(1-diphenylcarbamoyl-1H-imidazol-4-yl)-acetylamino]-propyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-methoxy-tetrahydro-furan-3-yl ester (289676-32-0)

Guidance literature:

Multi-step reaction with 8 steps

1: 100 percent / I₂; ceric ammonium nitrate

2: 89 percent / CuI; (Ph₃P)4P; Et₃N / dimethylformamide / 16 h

3: aq. NH₃ / 16 h / 4 °C

4: H₂ / 5 percent Pd/C / 24 h / 2068.59 Torr

5: EDC*HCl / dimethylformamide / 16 h

6: pyridine / 16 h

7: pyridine / 2 h

8: TCA / CH₂Cl₂ / 2 h

With pyridine; ammonium hydroxide; copper(l) iodide; ammonium cerium(IV) nitrate; (Ph₃P)4P; hydrogen; iodine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichloroacetic acid; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide; 1: Iodination / 2: Substitution / 3: ammonolysis / 4: Catalytic hydrogenation / 5: Condensation / 6: tritylation / 7: Acetylation / 8: acidolysis;

DOI:10.1016/S0960-894X(00)00226-2

Reference yield:

5-(3-Amino-prop-1-ynyl)-1-((2R,3R,4R,5R)-4-hydroxy-5-hydroxymethyl-3-methoxy-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione (289676-20-6) → acetic acid 5-(5-{3-[2-(1-diphenylcarbamoyl-1H-imidazol-4-yl)-acetylamino]-propyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-methoxy-tetrahydro-furan-3-yl ester (289676-32-0)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂ / 5 percent Pd/C / 24 h / 2068.59 Torr

2: EDC*HCl / dimethylformamide / 16 h

3: pyridine / 16 h

4: pyridine / 2 h

5: TCA / CH₂Cl₂ / 2 h

With pyridine; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichloroacetic acid; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide; 1: Catalytic hydrogenation / 2: Condensation / 3: tritylation / 4: Acetylation / 5: acidolysis;

DOI:10.1016/S0960-894X(00)00226-2

upstream raw materials:

2'-O-methyluridine

3',5'-di-O-acetyl-2'-O-methyluridine

5-(3-Amino-propyl)-1-((2R,3R,4R,5R)-4-hydroxy-5-hydroxymethyl-3-methoxy-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

5-(3-Amino-prop-1-ynyl)-1-((2R,3R,4R,5R)-4-hydroxy-5-hydroxymethyl-3-methoxy-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

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