(R)-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine-8-carboxamide

Base Information

Chemical Name:(R)-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine-8-carboxamide
CAS No.:1407830-70-9
Molecular Formula:C₁₉H₁₈ClN₅O
Molecular Weight:367.838
Hs Code.:

Synonyms:

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Chemical Property of (R)-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine-8-carboxamide

Chemical Property:

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Technology Process of (R)-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine-8-carboxamide

There total 7 articles about (R)-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1407830-61-8
(R)-8-bromo-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4Hbenzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine

: 1407830-70-9
(R)-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine-8-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / methanol / 12 h / 90 °C

2: ammonia / methanol / 12 h / 90 °C

With 1,3-bis-(diphenylphosphino)propane; ammonia; triethylamine; palladium diacetate; In methanol;

Reference yield:

: 1407833-48-0
methyl 3-(5-bromo-2-nitrophenylamino)-2-methylpropanoate

: 1407830-70-9
(R)-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine-8-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: ammonium chloride; iron / ethanol; water / 2 h / 60 °C

2: sodium / methanol / 0 - 20 °C

3: Lawessons reagent / tetrahydrofuran / 12 h / 80 °C

4: butan-1-ol / 12 h / 130 °C

5: caesium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 12 h / 110 °C / Inert atmosphere

6: Daicel AD-H / 38 °C / Resolution of racemate

7: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / methanol / 12 h / 90 °C

8: ammonia / methanol / 12 h / 90 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; Lawessons reagent; 1,3-bis-(diphenylphosphino)propane; ammonia; sodium; iron; ammonium chloride; caesium carbonate; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; methanol; ethanol; water; toluene; butan-1-ol;

Reference yield:

: 1407833-52-6
methyl 3-(2-amino-5-bromophenylamino)-2-methylpropanoate

: 1407830-70-9
(R)-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine-8-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: sodium / methanol / 0 - 20 °C

2: Lawessons reagent / tetrahydrofuran / 12 h / 80 °C

3: butan-1-ol / 12 h / 130 °C

4: caesium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 12 h / 110 °C / Inert atmosphere

5: Daicel AD-H / 38 °C / Resolution of racemate

6: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / methanol / 12 h / 90 °C

7: ammonia / methanol / 12 h / 90 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; Lawessons reagent; 1,3-bis-(diphenylphosphino)propane; ammonia; sodium; caesium carbonate; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; methanol; toluene; butan-1-ol;