N-[4-({(2S,5R)-5-[(R)-hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl}methyl)phenyl]-2-(2-oxopyrrolidin-1-yl)acetamide trifluoroacetamide

Base Information

Chemical Name:N-[4-({(2S,5R)-5-[(R)-hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl}methyl)phenyl]-2-(2-oxopyrrolidin-1-yl)acetamide trifluoroacetamide
CAS No.:1190609-33-6
Molecular Formula:C₂HF₃O₂*C₂₃H₂₈N₄O₃
Molecular Weight:522.524
Hs Code.:

Synonyms:

Suppliers and Price of N-[4-({(2S,5R)-5-[(R)-hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl}methyl)phenyl]-2-(2-oxopyrrolidin-1-yl)acetamide trifluoroacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[4-({(2S,5R)-5-[(R)-hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl}methyl)phenyl]-2-(2-oxopyrrolidin-1-yl)acetamide trifluoroacetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[4-({(2S,5R)-5-[(R)-hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl}methyl)phenyl]-2-(2-oxopyrrolidin-1-yl)acetamide trifluoroacetamide

There total 13 articles about N-[4-({(2S,5R)-5-[(R)-hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl}methyl)phenyl]-2-(2-oxopyrrolidin-1-yl)acetamide trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23100-12-1
6-chloronicotinylaldehyde

: 1190609-33-6
N-[4-({(2S,5R)-5-[(R)-hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl}methyl)phenyl]-2-(2-oxopyrrolidin-1-yl)acetamide trifluoroacetamide

Guidance literature:: Multi-step reaction with 14 steps

1.1: chloro-trimethyl-silane; triethylamine; magnesium chloride / ethyl acetate / 72 h / 20 °C

2.1: trifluoroacetic acid / methanol / 5 h / 20 °C

3.1: 2,6-dimethylpyridine / dichloromethane / 0 - 3 °C

4.1: water; dihydrogen peroxide; sodium hydroxide / tetrahydrofuran / 0 - 5 °C

4.2: 15 °C

4.3: 0 °C / pH 3

5.1: diphenyl phosphoryl azide; triethylamine / toluene / 6 h / 20 °C

5.2: 16 h / 100 °C

6.1: triethylamine / copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 15 h / 20 °C

7.1: pyrrolidine / N,N-dimethyl-formamide / 5 h / 80 °C

7.2: 3 h / 20 °C

8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

9.1: methanol; sodium cyanoborohydride / 0 °C

10.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

11.1: hydrogen; potassium acetate / palladium 10% on activated carbon / ethanol / 8 h / 2585.81 Torr

12.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h

13.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 20 °C

13.2: HPLC

14.1: hydrogenchloride / 1,3-dioxane; isopropyl alcohol / 1 h

14.2: HPLC

With pyrrolidine; 2,6-dimethylpyridine; hydrogenchloride; methanol; chloro-trimethyl-silane; 1-hydroxy-7-aza-benzotriazole; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; water; hydrogen; dihydrogen peroxide; potassium acetate; sodium cyanoborohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; magnesium chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,3-dioxane; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile;

Reference yield:

: 1190614-98-2
(R)-2-((S)-(6-chloropyridin-3-yl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid

: 1190609-33-6
N-[4-({(2S,5R)-5-[(R)-hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl}methyl)phenyl]-2-(2-oxopyrrolidin-1-yl)acetamide trifluoroacetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: diphenyl phosphoryl azide; triethylamine / toluene / 6 h / 20 °C

1.2: 16 h / 100 °C

2.1: triethylamine / copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 15 h / 20 °C

3.1: pyrrolidine / N,N-dimethyl-formamide / 5 h / 80 °C

3.2: 3 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.1: methanol; sodium cyanoborohydride / 0 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

7.1: hydrogen; potassium acetate / palladium 10% on activated carbon / ethanol / 8 h / 2585.81 Torr

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h

9.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 20 °C

9.2: HPLC

10.1: hydrogenchloride / 1,3-dioxane; isopropyl alcohol / 1 h

10.2: HPLC

With pyrrolidine; hydrogenchloride; methanol; 1-hydroxy-7-aza-benzotriazole; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; hydrogen; potassium acetate; sodium cyanoborohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,3-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile;

Reference yield:

: 1190614-99-3
5-((R)-((tert-butyldimethylsilyl)oxy)((2R,5S)-5-(4-nitrobenzyl)pyrrolidin-2-yl)methyl)-2-chloropyridine

: 1190609-33-6
N-[4-({(2S,5R)-5-[(R)-hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl}methyl)phenyl]-2-(2-oxopyrrolidin-1-yl)acetamide trifluoroacetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

2.1: hydrogen; potassium acetate / palladium 10% on activated carbon / ethanol / 8 h / 2585.81 Torr

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h

4.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 20 °C

4.2: HPLC

5.1: hydrogenchloride / 1,3-dioxane; isopropyl alcohol / 1 h

5.2: HPLC

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; tetrabutyl ammonium fluoride; hydrogen; potassium acetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,3-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;