IPI3063

Base Information

Chemical Name:IPI3063
CAS No.:1425043-73-7
Molecular Formula:C₂₅H₂₅N₇O₂
Molecular Weight:455.519
Hs Code.:

Synonyms:

Suppliers and Price of IPI3063

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Amino-6-[[(1S)-1-[8-(1,6-dihydro-1-methyl-6-oxo-3-pyridinyl)-1,2-dihydro-2-(1-methylethyl)-1-oxo-3-isoquinolinyl]ethyl]amino]-5-pyrimidinecarbonitrile
1mg
$ 205.00

TRC
4-Amino-6-[[(1S)-1-[8-(1,6-dihydro-1-methyl-6-oxo-3-pyridinyl)-1,2-dihydro-2-(1-methylethyl)-1-oxo-3-isoquinolinyl]ethyl]amino]-5-pyrimidinecarbonitrile
5mg
$ 635.00

ChemScene
IPI-3063 98.80%
25mg
$ 720.00

ChemScene
IPI-3063 98.80%
10mg
$ 360.00

ChemScene
IPI-3063 98.80%
5mg
$ 220.00

ChemScene
IPI-3063 98.80%
2mg
$ 120.00

Total 8 raw suppliers

Chemical Property of IPI3063

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

4-Amino-6-[[(1S)-1-[8-(1,6-dihydro-1-methyl-6-oxo-3-pyridinyl)-1,2-dihydro-2-(1-methylethyl)-1-oxo-3-isoquinolinyl]ethyl]amino]-5-pyrimidinecarbonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 4-Amino-6-[[(1S)-1-[8-(1,6-dihydro-1-methyl-6-oxo-3-pyridinyl)-1,2-dihydro-2-(1-methylethyl)-1-oxo-3-isoquinolinyl]ethyl]amino]-5-pyrimidinecarbonitrile, is a potent and selective PI3K p110δ inhibitor.

Technology Process of IPI3063

There total 5 articles about IPI3063 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1002309-52-5
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyridin-2-one

: 1425049-13-3
C₁₉H₁₉ClN₆O

: 1425043-73-7
C₂₅H₂₅N₇O₂

Guidance literature:: With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium carbonate; In 1,4-dioxane; water; for 4h; Reflux;

Reference yield:

: 21327-86-6
2-chloro-6-methylbenzoic acid

: 1425043-73-7
C₂₅H₂₅N₇O₂

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 2.17 h

1.2: 0.5 h / 20 °C

2.1: n-hexyllithium / tetrahydrofuran; hexane / 0.25 h / 0 - 5 °C

2.2: 1.75 h / 20 °C

3.1: sulfuric acid / Isopropyl acetate / 6 h / 50 - 70 °C

4.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 5 h / Reflux

5.1: sodium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 4 h / Reflux

With thionyl chloride; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sulfuric acid; n-hexyllithium; sodium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; Isopropyl acetate; water; butan-1-ol;

Reference yield:

: 1420627-50-4
C₁₄H₁₇ClN₂O

: 1425043-73-7
C₂₅H₂₅N₇O₂

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 5 h / Reflux

2: sodium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 4 h / Reflux

With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; butan-1-ol;