2(1H)-PYRIDINONE, 1-METHYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-

Base Information

• Chemical Name: 2(1H)-PYRIDINONE, 1-METHYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-
• CAS No.: 1002309-52-5
• Molecular Formula: C12H18BNO3
• Molecular Weight: 235.091
• Hs Code.: 2934999090
• Mol file: 1002309-52-5.mol

Synonyms:1-Methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyridin-2-one;1-methyl-6-oxo-1,6-dihydropyridin-3-ylboronic acid pinacol ester;RW2850;1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one;1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyridine-2-one;

Chemical Property of 2(1H)-PYRIDINONE, 1-METHYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-

Chemical Property:

• Boiling Point: 287.1±50.0 °C(Predicted)
• PKA: 0.03±0.62(Predicted)
• PSA: 40.46000
• Density: 1.09±0.1 g/cm3(Predicted)
• LogP: 0.68450
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one?is a useful research chemical.

Technology Process of 2(1H)-PYRIDINONE, 1-METHYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-

There total 12 articles about 2(1H)-PYRIDINONE, 1-METHYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-bromo-4-phenoxyaniline (1159607-48-3) + methanesulfonyl chloride (124-63-0) → 1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyridin-2-one (1002309-52-5)

Guidance literature:

3-bromo-4-phenoxyaniline; methanesulfonyl chloride; With triethylamine; In dichloromethane; at 20 ℃; for 1h;

With sodium hydroxide; In 1,4-dioxane; at 70 ℃; for 1h;

Reference yield: 64.0%

5-bromo-1-methylpyridin-2-(1H)-one + bis(pinacol)diborane (73183-34-3) → 1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyridin-2-one (1002309-52-5)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium hydroxide; tricyclohexylphosphine; In 1,4-dioxane; at 80 ℃; for 5h; Inert atmosphere;

Reference yield: 60.0%

→ 1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyridin-2-one (1002309-52-5)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 100 ℃; for 12h; Inert atmosphere;

upstream raw materials:

5-bromo-1-methylpyridin-2(1H)-one

bis(pinacol)diborane

2-methoxy-5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyridine

methyl iodide

Downstream raw materials:

(S)-tert-butyl 1-(1-amino-3-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)-1-oxopropan-2-ylcarbamoyl)cyclohexylcarbamate

(S)-tert-butyl 1-(1-amino-3-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)-1-oxopropan-2-ylcarbamoyl)cycloheptylcarbamate

CH₂O₂*C₃₁H₄₁N₅O₂

Refernces

• 1、 -. "PYRIDINONE DERIVATIVES AND THEIR USE AS SELECTIVE ALK-2 INHIBITORS". Page/Page column 48-49; 63. . Retrieved 2019/06/11.
• 2、 -. "SUBSTITUTED NITROGEN CONTAINING COMPOUNDS". Page/Page column 57; 58; 312. . Retrieved 2019/01/05.