(2S,4R)-4-(Acetylthio)-2-[[(aMinosulfonyl)[(1,1-diMethylethoxy)carbonyl]aMino]Methyl]-1-pyrrolidinecarboxylic Acid (4-Nitrophenyl) Ethyl Ester

Base Information

Chemical Name:(2S,4R)-4-(Acetylthio)-2-[[(aMinosulfonyl)[(1,1-diMethylethoxy)carbonyl]aMino]Methyl]-1-pyrrolidinecarboxylic Acid (4-Nitrophenyl) Ethyl Ester
CAS No.:571176-82-4
Molecular Formula:C₂₀H₂₈N₄O₉S₂
Molecular Weight:532.596
Hs Code.:
Mol file:571176-82-4.mol

(2S,4R)-4-(Acetylthio)-2-[[(aMinosulfonyl)[(1,1-diMethylethoxy)carbonyl]aMino]Methyl]-1-pyrrolidinecarboxylic Acid (4-Nitrophenyl) Ethyl Ester

Synonyms:

Suppliers and Price of (2S,4R)-4-(Acetylthio)-2-[[(aMinosulfonyl)[(1,1-diMethylethoxy)carbonyl]aMino]Methyl]-1-pyrrolidinecarboxylic Acid (4-Nitrophenyl) Ethyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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TRC
(2S,4R)-4-(Acetylthio)-2-[[(aminosulfonyl)[(1,1-dimethylethoxy)carbonyl]amino]methyl]-1-pyrrolidinecarboxylicAcid(4-Nitrophenyl)EthylEster
25mg
$ 1540.00

Total 7 raw suppliers

Chemical Property of (2S,4R)-4-(Acetylthio)-2-[[(aMinosulfonyl)[(1,1-diMethylethoxy)carbonyl]aMino]Methyl]-1-pyrrolidinecarboxylic Acid (4-Nitrophenyl) Ethyl Ester

Chemical Property:

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

(2S,4R)-4-(Acetylthio)-2-[[(aminosulfonyl)[(1,1-dimethylethoxy)carbonyl]amino]methyl]-1-pyrrolidinecarboxylicAcid(4-Nitrophenyl)EthylEster ^*data from reagent suppliers

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Useful:

Uses (2S,4R)-4-(Acetylthio)-2-[[(aminosulfonyl)[(1,1-dimethylethoxy)carbonyl]amino]methyl]-1-pyrrolidinecarboxylic Acid (4-Nitrophenyl) Ethyl Ester, is an intermediate in the synthesis of the 2-Aminomethylpyrrolidin-4-ylthio-Containing Side Chain of the Novel

Technology Process of (2S,4R)-4-(Acetylthio)-2-[[(aMinosulfonyl)[(1,1-diMethylethoxy)carbonyl]aMino]Methyl]-1-pyrrolidinecarboxylic Acid (4-Nitrophenyl) Ethyl Ester

There total 10 articles about (2S,4R)-4-(Acetylthio)-2-[[(aMinosulfonyl)[(1,1-diMethylethoxy)carbonyl]aMino]Methyl]-1-pyrrolidinecarboxylic Acid (4-Nitrophenyl) Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 104773-40-2
(2S,4S)-4-acetylthio-2-hydroxymethyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine

: 148017-28-1
N-tert-butoxycarbonylsulfamoyl amine

: 491878-06-9,571176-82-4
(2S,4S)-4-acetylthio-2-[[N-aminosulfonyl-N-(tert-butyloxycarbonyl)amino]methyl]pyrrolidine-1-carboxylic acid p-nitrobenzyl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In ethyl acetate; at 20 ℃; for 2h;
DOI:10.1021/op0340412

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 491878-06-9,571176-82-4
(2S,4S)-4-acetylthio-2-[[N-aminosulfonyl-N-(tert-butyloxycarbonyl)amino]methyl]pyrrolidine-1-carboxylic acid p-nitrobenzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / toluene; water; methanol / 1 h / 2 - 5 °C

2: triethylamine / toluene / 0.33 h / 20 °C

3: sodium tetrahydroborate / ethyl acetate; methanol / 3 h / 0 - 5 °C

4: toluene; N,N-dimethyl-formamide / 4 h / 65 °C / Large scale

5: di-isopropyl azodicarboxylate; triphenylphosphine / ethyl acetate / 2 h / 20 °C

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; potassium carbonate; triethylamine; triphenylphosphine; In methanol; water; ethyl acetate; N,N-dimethyl-formamide; toluene; 5: |Mitsunobu Displacement;
DOI:10.1021/op0340412

Reference yield:

: 51-35-4,30724-02-8
4R-4-hydroxyproline

: 491878-06-9,571176-82-4
(2S,4S)-4-acetylthio-2-[[N-aminosulfonyl-N-(tert-butyloxycarbonyl)amino]methyl]pyrrolidine-1-carboxylic acid p-nitrobenzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide / toluene; water / 1 h / 5 °C / Large scale

2: triethylamine / dichloromethane / 0.5 h / 0 °C / Large scale

3: triethylamine / dichloromethane / 0.5 h / -45 °C / Large scale

4: sodium tetrahydroborate / water; dichloromethane; isopropyl alcohol / 0.5 h / -45 °C / Large scale

5: toluene; N,N-dimethyl-formamide / 4 h / 65 °C / Large scale

6: di-isopropyl azodicarboxylate; triphenylphosphine / ethyl acetate / 2 h / 20 °C

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; sodium hydroxide; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 6: |Mitsunobu Displacement;
DOI:10.1021/op0340412