C₄₄H₆₂N₄O₈

Base Information

• Chemical Name: C₄₄H₆₂N₄O₈
• CAS No.: 944579-68-4
• Molecular Formula: C₄₄H₆₂N₄O₈
• Molecular Weight: 774.998
• Mol file: 944579-68-4.mol

Synonyms:

Chemical Property of C₄₄H₆₂N₄O₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₄H₆₂N₄O₈

There total 12 articles about C₄₄H₆₂N₄O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C22H34N2O5 → C44H62N4O8 (944579-68-4)

Guidance literature:

With oxygen; triethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2007.04.108

Reference yield:

3-benzyloxycarbonylamino-4-methanesulfonyloxy-butyric acid tert-butyl ester (169498-46-8) → C44H62N4O8 (944579-68-4)

Guidance literature:

Multi-step reaction with 9 steps

1.1: (n-Hex)CuCNLi₂ / tetrahydrofuran / -40 °C

2.1: 91 percent / triethylamine; dimethylaminopyridine / CH₂Cl₂ / 12 h / 0 °C

3.1: CuI / hexane; diethyl ether / 0.42 h / -20 °C

3.2: 70 percent / hexane; diethyl ether / 4.83 h / -30 °C

4.1: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / 20 °C

5.1: dimethylaminopyridine; N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 12 h / 20 °C

6.1: 3.33 g / 5 h / Heating

7.1: 98 percent / aq. NaNO₂ / acetic acid / 12 h / 20 °C

8.1: zinc; acetic acid / 12 h / 20 °C

9.1: 400 mg / triethylamine; O₂ / CH₂Cl₂ / 1 h / 20 °C

With dmap; copper(l) iodide; oxygen; acetic acid; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc; sodium nitrite; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; acetic acid;

DOI:10.1016/j.tetlet.2007.04.108

Reference yield:

C22H35NO4 → C44H62N4O8 (944579-68-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / 20 °C

2: dimethylaminopyridine; N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 12 h / 20 °C

3: 3.33 g / 5 h / Heating

4: 98 percent / aq. NaNO₂ / acetic acid / 12 h / 20 °C

5: zinc; acetic acid / 12 h / 20 °C

6: 400 mg / triethylamine; O₂ / CH₂Cl₂ / 1 h / 20 °C

With dmap; oxygen; acetic acid; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc; sodium nitrite; In dichloromethane; acetic acid;

DOI:10.1016/j.tetlet.2007.04.108

upstream raw materials:

3-benzyloxycarbonylamino-4-methanesulfonyloxy-butyric acid tert-butyl ester

ethyl (5R)-5-(benzyloxycarbonylamino)-3-oxododecanoate

Z-D(tBu)-OH

n-hexyllithium