(6S,9R)-2,2,2-trichloroethyl 2-(4-aminophenyl)-4-((S)-3-methylmorpholino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidine-10-carboxylate

Base Information

Chemical Name:(6S,9R)-2,2,2-trichloroethyl 2-(4-aminophenyl)-4-((S)-3-methylmorpholino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidine-10-carboxylate
CAS No.:1428902-79-7
Molecular Formula:C₂₃H₂₆Cl₃N₅O₃
Molecular Weight:526.85
Hs Code.:

(6S,9R)-2,2,2-trichloroethyl 2-(4-aminophenyl)-4-((S)-3-methylmorpholino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidine-10-carboxylate

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Chemical Property of (6S,9R)-2,2,2-trichloroethyl 2-(4-aminophenyl)-4-((S)-3-methylmorpholino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidine-10-carboxylate

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Technology Process of (6S,9R)-2,2,2-trichloroethyl 2-(4-aminophenyl)-4-((S)-3-methylmorpholino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidine-10-carboxylate

There total 6 articles about (6S,9R)-2,2,2-trichloroethyl 2-(4-aminophenyl)-4-((S)-3-methylmorpholino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidine-10-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₂₁Cl₃N₂O₃

: 1428902-79-7
(6S,9R)-2,2,2-trichloroethyl 2-(4-aminophenyl)-4-((S)-3-methylmorpholino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidine-10-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 7.17 h / 0 - 25 °C

2: 2-chloropyridine; trifluoromethylsulfonic anhydride / dichloromethane / 0.68 h / -78 - 25 °C

3: ammonium chloride; iron / ethanol; water / 2 h / Reflux

With 2-chloropyridine; trifluoromethylsulfonic anhydride; iron; ammonium chloride; triethylamine; In ethanol; dichloromethane; water;
DOI:10.1021/jm400194n

Reference yield:

: 1428902-78-6
(6S,9R)-2,2,2-trichloroethyl 4-((S)-3-methylmorpholino)-2-(4-nitrophenyl)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidine-10-carboxylate

: 1428902-79-7
(6S,9R)-2,2,2-trichloroethyl 2-(4-aminophenyl)-4-((S)-3-methylmorpholino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidine-10-carboxylate

Guidance literature:: With iron; ammonium chloride; In ethanol; water; for 2h; Reflux;
DOI:10.1021/jm400194n

Reference yield:

: 8-benzyl-8-azabicyclo[3.2.1]octan-2-one

: 1428902-79-7
(6S,9R)-2,2,2-trichloroethyl 2-(4-aminophenyl)-4-((S)-3-methylmorpholino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidine-10-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: Resolution of racemate

2: acetonitrile / 24 h / 25 °C

3: titanium(IV) tetraethanolate / dichloromethane / 16 h / Reflux

4: triethylamine / dichloromethane / 7.17 h / 0 - 25 °C

5: 2-chloropyridine; trifluoromethylsulfonic anhydride / dichloromethane / 0.68 h / -78 - 25 °C

6: ammonium chloride; iron / ethanol; water / 2 h / Reflux

With 2-chloropyridine; titanium(IV) tetraethanolate; trifluoromethylsulfonic anhydride; iron; ammonium chloride; triethylamine; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm400194n