methyl (2R,3S,2'S)-3--2-methyl-3-phenylpropionate

Base Information

• Chemical Name: methyl (2R,3S,2'S)-3--2-methyl-3-phenylpropionate
• CAS No.: 94100-74-0
• Molecular Formula: C₂₁H₂₁F₃O₅
• Molecular Weight: 410.39
• Mol file: 94100-74-0.mol

Synonyms:

Chemical Property of methyl (2R,3S,2'S)-3--2-methyl-3-phenylpropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2R,3S,2'S)-3--2-methyl-3-phenylpropionate

There total 10 articles about methyl (2R,3S,2'S)-3--2-methyl-3-phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,3R)-methyl 3-hydroxy-2-methyl-3-phenylpropionate (94199-26-5) + (R)-methoxytrifluoromethylphenylacetyl chloride (20445-33-4,39637-99-5) → methyl (2S,3R,2'S)-3--2-methyl-3-phenylpropionate (94100-74-0,94199-27-6) + methyl (2R,3S,2'S)-3--2-methyl-3-phenylpropionate (94100-74-0,94199-27-6)

Guidance literature:

With pyridine; In tetrachloromethane; at 20 ℃; Title compound not separated from byproducts;

Reference yield:

(2S,3R)-methyl 3-hydroxy-2-methyl-3-phenylpropionate (94199-26-5) + (R)-methoxytrifluoromethylphenylacetyl chloride (20445-33-4,39637-99-5) → methyl (2S,3R,2'S)-3--2-methyl-3-phenylpropionate (94100-74-0,94199-27-6) + methyl (2R,3S,2'S)-3--2-methyl-3-phenylpropionate (94100-74-0,94199-27-6)

Guidance literature:

With pyridine; In tetrachloromethane; at 20 ℃; Title compound not separated from byproducts;

Reference yield:

(R)-methoxytrifluoromethylphenylacetyl chloride (20445-33-4,39637-99-5) + (2R,3S)-methyl 3-hydroxy-2-methyl-3-phenylpropanoate (36041-80-2) → methyl (2S,3R,2'S)-3--2-methyl-3-phenylpropionate (94100-74-0,94199-27-6) + methyl (2R,3S,2'S)-3--2-methyl-3-phenylpropionate (94100-74-0,94199-27-6)

Guidance literature:

With pyridine; In tetrachloromethane; at 20 ℃; for 15h; Title compound not separated from byproducts;

upstream raw materials:

(2S,3R)-methyl 3-hydroxy-2-methyl-3-phenylpropionate

(R)-methoxytrifluoromethylphenylacetyl chloride

(2R,3S)-methyl 3-hydroxy-2-methyl-3-phenylpropanoate

(+)-(2S,3R)-3-hydroxy-2-methyl-3-phenylpropanoic acid