36041-80-2

Basic information

• Product Name: (2R,3S)-methyl 3-hydroxy-2-methyl-3-phenylpropanoate
• Synonyms: (2R,3S)-methyl 3-hydroxy-2-methyl-3-phenylpropanoate
• CAS NO: 36041-80-2
• Molecular Weight: 194.23
• Mol File: 36041-80-2.mol
• Article Data: 110

Chemical Properties

• CAS DataBase Reference: (2R,3S)-methyl 3-hydroxy-2-methyl-3-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-methyl 3-hydroxy-2-methyl-3-phenylpropanoate(36041-80-2)
• EPA Substance Registry System: (2R,3S)-methyl 3-hydroxy-2-methyl-3-phenylpropanoate(36041-80-2)

Safety Data

• Hazardous Substances Data: 36041-80-2(Hazardous Substances Data)

Upstream product

• 554-12-1 propanoic acid methyl ester 
• 100-52-7 benzaldehyde 
• 17639-93-9 2-chloro-propionic acid methyl ester 
• 14366-86-0 (2RS, 3SR)-3-hydroxy-2-methyl-3-phenylpropanoic acid 
• 166588-79-0 1-((4R,7S)-7-Isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-indazol-2-yl)-3-phenyl-propan-1-one 
• 18020-59-2 methyl 3-hydroxy-2-methylidene-3-phenylpropionate 
• 5445-17-0 Methyl 2-bromopropionate 
• 72658-09-4 (E)-(1-methoxyprop-1-enyloxy)trimethylsilane 
• 89337-61-1 tert-butyl((1-methoxyprop-1-en-1-yl)oxy)dimethylsilane 
• 292638-85-8 acrylic acid methyl ester 
• 76454-71-2 erythro-N,N-dimethyl-3-hydroxy-2-methyldihydrothiocinnamide 
• 20047-41-0 (2R)-methyl 2-bromopropionate 
• 94198-90-0 (CO)5Cr(C(OCH₃)CH(CH₃)CH(C₆H₅)OH) 
• 110164-86-8 (4S,5R)-3-Bromo-4-methyl-5-phenyl-4,5-dihydro-isoxazole 

Downstream Products

• 36393-58-5 anti-3-hydroxy-2-methyl-3-phenylpropanylamine 
• 36391-82-9 5r-methyl-6t-phenyl-[1,3]oxazinan-2-one 
• 94199-26-5 (2S,3R)-methyl 3-hydroxy-2-methyl-3-phenylpropionate 
• 7087-77-6 (1S,2S)-2-methyl-1-phenyl-propane-1,3-diol 
• 36041-79-9 (-)-(2R,3S)-3-hydroxy-2-methyl-3-phenylpropionic acid 

Relevant articles and documents

Application of axially dissymmetric ligand recoverable with fluorous solvent as a chiral auxiliary

(Ra)-(R)2-2,2′-Bis(1-hydroxy-1H-perfluorooctyl)biphenyl ((Ra)-(R)2-1c), which is an axially dissymmetric ligand with two chiral centers, works as a good chiral auxiliary for asymmetric aldol reaction. Thus, the reaction of monopropan

Fe-Catalyzed Anaerobic Mukaiyama-Type Hydration of Alkenes using Nitroarenes

Hydration of alkenes using first row transition metals (Fe, Co, Mn) under oxygen atmosphere (Mukaiyama-type hydration) is highly practical for alkene functionalization in complex synthesis. Different hydration protocols have been developed, however, control of the stereoselectivity remains a challenge. Herein, highly diastereoselective Fe-catalyzed anaerobic Markovnikov-selective hydration of alkenes using nitroarenes as oxygenation reagents is reported. The nitro moiety is not well explored in radical chemistry and nitroarenes are known to suppress free radical processes. Our findings show the potential of cheap nitroarenes as oxygen donors in radical transformations. Secondary and tertiary alcohols were prepared with excellent Markovnikov-selectivity. The method features large functional group tolerance and is also applicable for late-stage chemical functionalization. The anaerobic protocol outperforms existing hydration methodology in terms of reaction efficiency and selectivity.

Manganese-Catalyzed anti-Selective Asymmetric Hydrogenation of α-Substituted β-Ketoamides

A Mn-catalyzed diastereo- and enantioselective hydrogenation of α-substituted β-ketoamides has been realized for the first time under dynamic kinetic resolution conditions. anti-α-Substituted β-hydroxy amides, which are useful building blocks for the synthesis of bioactive molecules and chiral drugs, were prepared in high yields with excellent selectivity (up to >99 percent dr and >99 percent ee) and unprecedentedly high activity (TON up to 10000). The origin of the excellent stereoselectivity was clarified by DFT calculations.