Technology Process of 1,2,5-trimethoxy-3-methyl-4-(trimethylsilylethynyl)benzene
There total 5 articles about 1,2,5-trimethoxy-3-methyl-4-(trimethylsilylethynyl)benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine;
at 60 ℃;
for 240h;
Inert atmosphere;
Sealed tube;
DOI:10.1039/c3ob42333f
- Guidance literature:
-
Multi-step reaction with 4 steps
1: dihydrogen peroxide; sulfuric acid / methanol; water / 0.33 h / 0 °C
2: potassium carbonate / N,N-dimethyl-formamide / 24 h / Inert atmosphere; Darkness
3: N-iodo-succinimide; trifluoroacetic acid / acetonitrile / 0.5 h / Inert atmosphere; Darkness
4: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 240 h / 60 °C / Inert atmosphere; Sealed tube
With
bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; copper(l) iodide; sulfuric acid; dihydrogen peroxide; potassium carbonate; triethylamine; trifluoroacetic acid;
In
methanol; water; N,N-dimethyl-formamide; acetonitrile;
4: |Sonogashira Cross-Coupling;
DOI:10.1039/c3ob42333f
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 24 h / Inert atmosphere; Darkness
2: N-iodo-succinimide; trifluoroacetic acid / acetonitrile / 0.5 h / Inert atmosphere; Darkness
3: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 240 h / 60 °C / Inert atmosphere; Sealed tube
With
bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; copper(l) iodide; potassium carbonate; triethylamine; trifluoroacetic acid;
In
N,N-dimethyl-formamide; acetonitrile;
3: |Sonogashira Cross-Coupling;
DOI:10.1039/c3ob42333f