resolvin E2

Base Information

• Chemical Name: resolvin E2
• CAS No.: 865532-70-3
• Molecular Formula: C₂₀H₃₀O₄
• Molecular Weight: 334.456
• Mol file: 865532-70-3.mol

Synonyms:

Chemical Property of resolvin E2

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

ResolvinE2 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Resolvin E2 is a potent antiinflammatory compound derived from the omega-3 polyunsatrated fatty acid eicosapentaenoic acid (EPA). Resolvin E2 was shown to be biologically active in blocking neutrophil infiltration and reducing proinflammatory cytokines in the acute peritonitis model.

Technology Process of resolvin E2

There total 29 articles about resolvin E2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(5S,6E,8Z,11Z,14Z,16E,18R)-5,18-dihydroxy-6,8,11,14,16-eicosapentaenoic acid methyl ester (1367197-27-0) → resolvin E2 (865532-70-3)

Guidance literature:

(5S,6E,8Z,11Z,14Z,16E,18R)-5,18-dihydroxy-6,8,11,14,16-eicosapentaenoic acid methyl ester; With lithium hydroxide; In methanol; water; at 0 ℃;

With sodium dihydrogenphosphate; In ethyl acetate;

DOI:10.1016/j.tetlet.2012.01.136

Reference yield: 78.0%

methyl (5S,6E,8Z,11Z,14Z,16E,18R)-5,18-bis[(tert-butyldimethylsilyl)oxy]icosa-6,8,11,14,16-pentaenoate → resolvin E2 (865532-70-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/acs.orglett.6b02612

Reference yield:

5S-hydroperoxy, 18R/S-hydroxy-EPE (865532-69-0) → resolvin E2 (865532-70-3)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 0.5 - 0.666667h;

upstream raw materials:

5S-hydroperoxy, 18R/S-hydroxy-EPE

C₃₂H₅₈O₄Si₂

C₁₄H₃₀OSi₂

(R,E)-tert-butyl((1-iodopent-1-en-3-yl)oxy)dimethylsilane

Refernces

• 1、 Fukuda, Hayato,Muromoto, Ryuta,Takakura, Yuuki,Ishimura, Kohei,Kanada, Ryutaro,Fushihara, Daichi,Tanabe, Makoto,Matsubara, Kotaro,Hirao, Toru,Hirashima, Koki,Abe, Hiroshi,Arisawa, Mitsuhiro,Matsuda, Tadashi,Shuto, Satoshi. "Design and Synthesis of Cyclopropane Congeners of Resolvin E2, an Endogenous Proresolving Lipid Mediator, as Its Stable Equivalents". . p. 6224 - 6227. Retrieved 2016.
• 2、 -. "USE OF DOCOSATRIENES, RESOLVINS AND THEIR STABLE ANALOGS IN THE TREATMENT OF AIRWAY DISEASES AND ASTHMA". Page/Page column 19/31. . Retrieved 2008/06/13.