(S)-2-{(S)-2-[2-(2-{(S)-3-(4-Hydroxy-phenyl)-2-[((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-3a-ylmethyl)-amino]-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid

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Chemical Name:(S)-2-{(S)-2-[2-(2-{(S)-3-(4-Hydroxy-phenyl)-2-[((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-3a-ylmethyl)-amino]-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid
CAS No.:177895-43-1
Molecular Formula:C₄₀H₅₅N₅O₁₂
Molecular Weight:797.903
Hs Code.:

(S)-2-{(S)-2-[2-(2-{(S)-3-(4-Hydroxy-phenyl)-2-[((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-3a-ylmethyl)-amino]-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid

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Chemical Property of (S)-2-{(S)-2-[2-(2-{(S)-3-(4-Hydroxy-phenyl)-2-[((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-3a-ylmethyl)-amino]-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid

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Technology Process of (S)-2-{(S)-2-[2-(2-{(S)-3-(4-Hydroxy-phenyl)-2-[((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-3a-ylmethyl)-amino]-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid

There total 6 articles about (S)-2-{(S)-2-[2-(2-{(S)-3-(4-Hydroxy-phenyl)-2-[((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-3a-ylmethyl)-amino]-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₄₃N₃O₁₂

: L-phenylalanyl-L-leucine trifluoroacetic acid

: 177895-43-1
(S)-2-{(S)-2-[2-(2-{(S)-3-(4-Hydroxy-phenyl)-2-[((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-3a-ylmethyl)-amino]-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid

Guidance literature:: With 4-methyl-morpholine; In tetrahydrofuran; at -15 - 20 ℃; for 3.3h; Yield given;
DOI:10.1039/P29960000789

Reference yield:

: 32786-02-0
2,3:4,5-bis-O-(isopropylidene)-D-fructopyranose aldehyde

: 177895-43-1
(S)-2-{(S)-2-[2-(2-{(S)-3-(4-Hydroxy-phenyl)-2-[((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-3a-ylmethyl)-amino]-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 56 percent / NaBH₃CN / methanol; H₂O / 5 h / 70 °C

2: DCC / dimethylformamide / 0 - 20 °C

3: aq. Na₂CO₃ / 1 h

4: N-methylmorpholine / tetrahydrofuran / 0.03 h / -15 °C

5: N-methylmorpholine / tetrahydrofuran / 3.3 h / -15 - 20 °C

With 4-methyl-morpholine; sodium cyanoborohydride; sodium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1039/P29960000789

Reference yield:

: 60-18-4,18875-48-4,25619-78-7,30704-25-7
L-tyrosine

: 177895-43-1
(S)-2-{(S)-2-[2-(2-{(S)-3-(4-Hydroxy-phenyl)-2-[((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-3a-ylmethyl)-amino]-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 56 percent / NaBH₃CN / methanol; H₂O / 5 h / 70 °C

2: DCC / dimethylformamide / 0 - 20 °C

3: aq. Na₂CO₃ / 1 h

4: N-methylmorpholine / tetrahydrofuran / 0.03 h / -15 °C

5: N-methylmorpholine / tetrahydrofuran / 3.3 h / -15 - 20 °C

With 4-methyl-morpholine; sodium cyanoborohydride; sodium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1039/P29960000789