C₂₅H₃₈N₂O₄

Base Information

• Chemical Name: C₂₅H₃₈N₂O₄
• CAS No.: 1363328-31-7
• Molecular Formula: C₂₅H₃₈N₂O₄
• Molecular Weight: 430.588
• Mol file: 1363328-31-7.mol

Synonyms:

Chemical Property of C₂₅H₃₈N₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₃₈N₂O₄

There total 12 articles about C₂₅H₃₈N₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-N-((3S,5S)-3,5-dimethyl-8-oxo-8-((R)-2-oxo-4-phenyloxazolidin-3-yl)oct-6-en-1-yl)-2-methylbutanamide + methylmagnesium bromide (75-16-1) → C25H38N2O4 (1363328-31-7)

Guidance literature:

methylmagnesium bromide; With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; at -78 ℃; for 0.333333h; Inert atmosphere;

(R)-N-((3S,5S)-3,5-dimethyl-8-oxo-8-((R)-2-oxo-4-phenyloxazolidin-3-yl)oct-6-en-1-yl)-2-methylbutanamide; In tetrahydrofuran; at -78 - -40 ℃; Inert atmosphere;

DOI:10.1021/jo201951s

Reference yield:

(R)-N-((3S,5S)-6-hydroxy-3,5-dimethylhexyl)-2-methylbutanamide (1351186-36-1) → C25H38N2O4 (1363328-31-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

3.2: -78 - -40 °C / Inert atmosphere

With oxalyl dichloride; copper(I) bromide dimethylsulfide complex; sodium hexamethyldisilazane; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; 1.1: Swern oxidation / 1.2: Swern oxidation / 2.2: Horner-Wadsworth-Emmons olefination;

DOI:10.1021/jo201951s

Reference yield:

C13H25NO2 → C25H38N2O4 (1363328-31-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

2.2: -78 - -40 °C / Inert atmosphere

With copper(I) bromide dimethylsulfide complex; sodium hexamethyldisilazane; In tetrahydrofuran; 1.2: Horner-Wadsworth-Emmons olefination;

DOI:10.1021/jo201951s

upstream raw materials:

(R)-N-((3S,5S)-6-hydroxy-3,5-dimethylhexyl)-2-methylbutanamide

methylmagnesium bromide

(R)-3-((S,E)-6-(tert-butyldiphenylsilyloxy)-5-methylhex-2-enoyl)-4-phenyloxazolidin-2-one

(R)-3-((3S,5S)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexanoyl)-4-phenyloxazolidin-2-one

Downstream raw materials:

(3R,4S,6S)-3,4,6-trimethyl-8-((R)-2-methylbutanamido)-N-((R)-1-(tritylthio)but-3-en-2-yl)octanamide