2-((2R,5S,8R,11S,14R,17S,20R,23S)-14-benzyl-5,11,17,23-tetraisobutyl-4,8,16,22-hexamethyl-3,6,9,12,15,18,21,24-octaoxo-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclo-tetracosan-2-yl)acetic acid

Base Information

• Chemical Name: 2-((2R,5S,8R,11S,14R,17S,20R,23S)-14-benzyl-5,11,17,23-tetraisobutyl-4,8,16,22-hexamethyl-3,6,9,12,15,18,21,24-octaoxo-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclo-tetracosan-2-yl)acetic acid
• CAS No.: 189131-13-3
• Molecular Formula: C₄₇H₇₂N₄O₁₄
• Molecular Weight: 917.107
• Mol file: 189131-13-3.mol

Synonyms:

Chemical Property of 2-((2R,5S,8R,11S,14R,17S,20R,23S)-14-benzyl-5,11,17,23-tetraisobutyl-4,8,16,22-hexamethyl-3,6,9,12,15,18,21,24-octaoxo-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclo-tetracosan-2-yl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((2R,5S,8R,11S,14R,17S,20R,23S)-14-benzyl-5,11,17,23-tetraisobutyl-4,8,16,22-hexamethyl-3,6,9,12,15,18,21,24-octaoxo-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclo-tetracosan-2-yl)acetic acid

There total 2 articles about 2-((2R,5S,8R,11S,14R,17S,20R,23S)-14-benzyl-5,11,17,23-tetraisobutyl-4,8,16,22-hexamethyl-3,6,9,12,15,18,21,24-octaoxo-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclo-tetracosan-2-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C60H82N4O14 (189159-97-5) → 2-((2R,5S,8R,11S,14R,17S,20R,23S)-14-benzyl-5,11,17,23-tetraisobutyl-4,8,16,22-hexamethyl-3,6,9,12,15,18,21,24-octaoxo-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclo-tetracosan-2-yl)acetic acid (189131-13-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 3.5h;

DOI:10.1271/bbb.110129

Reference yield:

PF1022A antipode (133413-70-4) + acetonitrile (75-05-8,26809-02-9) → 2,2'-((2R,5S,8R,11S,14R,17S,20R,23S)-5,11,17,23-tetraisobutyl-4,8,10,16,20,22-hexamethyl-3,6,9,12,15,18,21,24-octaoxo-1,7,13,19-tetraoxa-4,10,16,22-tetra-azacyclo-tetracosane2,14-diyl)diacetic acid (189159-45-3) + 2-((2R,5S,8R,11S,14R,17S,20R,23S)-14-benzyl-5,11,17,23-tetraisobutyl-4,8,16,22-hexamethyl-3,6,9,12,15,18,21,24-octaoxo-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclo-tetracosan-2-yl)acetic acid (189131-13-3)

Guidance literature:

With ruthenium trichloride; periodic acid; In tetrachloromethane; water; at 20 ℃;

DOI:10.1271/bbb.110129

Reference yield: 13.0%

2-((2R,5S,8R,11S,14R,17S,20R,23S)-14-benzyl-5,11,17,23-tetraisobutyl-4,8,16,22-hexamethyl-3,6,9,12,15,18,21,24-octaoxo-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclo-tetracosan-2-yl)acetic acid (189131-13-3) + 1,2-diamino-benzene (95-54-5) → (3S,6R,9S,12R,15S,18R,21S,24R)-6-((1H-benzo[d]imidazol-2-yl)methyl)-18-benzyl-3,9,15,21-tetraisobutyl-4,10,12,16,22,24-hexamethyl-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclotetracosan-2,5,8,11,14,17,20,23-octanone (189159-87-3)

Guidance literature:

With trifluoromethylsulfonic anhydride; Triphenylphosphine oxide; In 1,1-dichloroethane; dichloromethane; at 0 - 80 ℃; Inert atmosphere;

DOI:10.1271/bbb.110129

upstream raw materials:

C₆₀H₈₂N₄O₁₄

PF1022A antipode

acetonitrile

Downstream raw materials:

C₅₃H₈₄N₆O₁₄

C₅₇H₈₄N₆O₁₄

(3S,6R,9S,12R,15S,18R,21S,24R)-6-((1H-benzo[d]imidazol-2-yl)methyl)-18-benzyl-3,9,15,21-tetraisobutyl-4,10,12,16,22,24-hexamethyl-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclotetracosan-2,5,8,11,14,17,20,23-octanone