Technology Process of (3S,6R,9S,12R,15S,18R,21S,24R)-6-((1H-benzo[d]imidazol-2-yl)methyl)-18-benzyl-3,9,15,21-tetraisobutyl-4,10,12,16,22,24-hexamethyl-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclotetracosan-2,5,8,11,14,17,20,23-octanone
There total 3 articles about (3S,6R,9S,12R,15S,18R,21S,24R)-6-((1H-benzo[d]imidazol-2-yl)methyl)-18-benzyl-3,9,15,21-tetraisobutyl-4,10,12,16,22,24-hexamethyl-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclotetracosan-2,5,8,11,14,17,20,23-octanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
-
-
189131-13-3
2-((2R,5S,8R,11S,14R,17S,20R,23S)-14-benzyl-5,11,17,23-tetraisobutyl-4,8,16,22-hexamethyl-3,6,9,12,15,18,21,24-octaoxo-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclo-tetracosan-2-yl)acetic acid
-
-
189159-87-3
(3S,6R,9S,12R,15S,18R,21S,24R)-6-((1H-benzo[d]imidazol-2-yl)methyl)-18-benzyl-3,9,15,21-tetraisobutyl-4,10,12,16,22,24-hexamethyl-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclotetracosan-2,5,8,11,14,17,20,23-octanone
- Guidance literature:
-
With
trifluoromethylsulfonic anhydride; Triphenylphosphine oxide;
In
1,1-dichloroethane; dichloromethane;
at 0 - 80 ℃;
Inert atmosphere;
DOI:10.1271/bbb.110129
-
-
189159-87-3
(3S,6R,9S,12R,15S,18R,21S,24R)-6-((1H-benzo[d]imidazol-2-yl)methyl)-18-benzyl-3,9,15,21-tetraisobutyl-4,10,12,16,22,24-hexamethyl-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclotetracosan-2,5,8,11,14,17,20,23-octanone
- Guidance literature:
-
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 3.5 h / 20 °C
2: trifluoromethylsulfonic anhydride; Triphenylphosphine oxide / 1,1-dichloroethane; dichloromethane / 0 - 80 °C / Inert atmosphere
With
trifluoromethylsulfonic anhydride; palladium 10% on activated carbon; hydrogen; Triphenylphosphine oxide;
In
methanol; 1,1-dichloroethane; dichloromethane;
DOI:10.1271/bbb.110129
-
-
189159-87-3
(3S,6R,9S,12R,15S,18R,21S,24R)-6-((1H-benzo[d]imidazol-2-yl)methyl)-18-benzyl-3,9,15,21-tetraisobutyl-4,10,12,16,22,24-hexamethyl-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclotetracosan-2,5,8,11,14,17,20,23-octanone
- Guidance literature:
-
Multi-step reaction with 2 steps
1: ruthenium trichloride; periodic acid / tetrachloromethane; water / 20 °C
2: trifluoromethylsulfonic anhydride; Triphenylphosphine oxide / 1,1-dichloroethane; dichloromethane / 0 - 80 °C / Inert atmosphere
With
ruthenium trichloride; trifluoromethylsulfonic anhydride; periodic acid; Triphenylphosphine oxide;
In
tetrachloromethane; 1,1-dichloroethane; dichloromethane; water;
DOI:10.1271/bbb.110129
