Technology Process of sodium 2-[3-cyano-4-(1H-pyrazol-1-yl)phenyl]isonicotinate
There total 5 articles about sodium 2-[3-cyano-4-(1H-pyrazol-1-yl)phenyl]isonicotinate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: cesium fluoride / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane / Heating / reflux
2: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C
3: methanol; sodium hydroxide; water / tetrahydrofuran / 0.67 h / 80 °C
4: ethanol; water / 0.25 h / 20 °C
With
methanol; sodium hydroxide; potassium tert-butylate; water; cesium fluoride;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: cesium fluoride / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane / Heating / reflux
2: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C
3: methanol; sodium hydroxide; water / tetrahydrofuran / 0.67 h / 80 °C
4: ethanol; water / 0.25 h / 20 °C
With
methanol; sodium hydroxide; potassium tert-butylate; water; cesium fluoride;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: methanol; sodium hydroxide; water / tetrahydrofuran / 0.67 h / 80 °C
2: ethanol; water / 0.25 h / 20 °C
With
methanol; sodium hydroxide; water;
In
tetrahydrofuran; ethanol; water;
