Technology Process of C18H27NO2
There total 4 articles about C18H27NO2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
trimethylsilyl cyanide;
With
titanium(IV) isopropylate; C23H16N2O2;
In
dichloromethane;
at -40 ℃;
Inert atmosphere;
10-benzyloxy-1-decanal;
In
dichloromethane;
at -40 ℃;
for 48h;
Inert atmosphere;
With
hydrogenchloride;
In
dichloromethane; water;
Overall yield = 88 %; Overall yield = 0.51 g; enantioselective reaction;
DOI:10.1002/chem.201300827
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: pyridinium chlorochromate; silica gel / dichloromethane / 3 h / Inert atmosphere
2.1: titanium(IV) isopropylate; C23H16N2O2 / dichloromethane / -40 °C / Inert atmosphere
2.2: 48 h / -40 °C / Inert atmosphere
With
titanium(IV) isopropylate; C23H16N2O2; silica gel; pyridinium chlorochromate;
In
dichloromethane;
DOI:10.1002/chem.201300827
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 4 h / 0 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: pyridinium chlorochromate; silica gel / dichloromethane / 3 h / Inert atmosphere
3.1: titanium(IV) isopropylate; C23H16N2O2 / dichloromethane / -40 °C / Inert atmosphere
3.2: 48 h / -40 °C / Inert atmosphere
With
titanium(IV) isopropylate; C23H16N2O2; silica gel; sodium hydride; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201300827
