2-{2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-acetylamino}-3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid benzyl ester

Base Information

Chemical Name:2-{2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-acetylamino}-3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid benzyl ester
CAS No.:244280-47-5
Molecular Formula:C₃₃H₃₂N₄O₇
Molecular Weight:596.64
Hs Code.:

2-{2-[(9<i>H</i>-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-acetylamino}-3-(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-propionic acid benzyl ester

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Chemical Property of 2-{2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-acetylamino}-3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid benzyl ester

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Technology Process of 2-{2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-acetylamino}-3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid benzyl ester

There total 4 articles about 2-{2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-acetylamino}-3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 244280-47-5
2-{2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-acetylamino}-3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydride / dimethylformamide

1.2: 35 percent / Cs₂CO₃ / dimethylformamide / pH 7

2.1: trifluoroacetic acid; thioanisol / CH₂Cl₂

3.1: ByBoP; diisopropylethylamine / CH₂Cl₂

With methyl-phenyl-thioether; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; lithium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1.1: Alkylation / 1.2: benzylation / 2.1: Hydrolysis / 3.1: Condensation;
DOI:10.1080/07328319908044779

Reference yield:

: 65-71-4,28806-14-6,691841-57-3
thymin

: 244280-47-5
2-{2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-acetylamino}-3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydride / dimethylformamide

1.2: 35 percent / Cs₂CO₃ / dimethylformamide / pH 7

2.1: trifluoroacetic acid; thioanisol / CH₂Cl₂

3.1: ByBoP; diisopropylethylamine / CH₂Cl₂

With methyl-phenyl-thioether; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; lithium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1.1: Alkylation / 1.2: benzylation / 2.1: Hydrolysis / 3.1: Condensation;
DOI:10.1080/07328319908044779

Reference yield:

: 244280-46-4
2-tert-butoxycarbonylamino-3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)propionic acid benzyl ester

: 244280-47-5
2-{2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-acetylamino}-3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid; thioanisol / CH₂Cl₂

2: ByBoP; diisopropylethylamine / CH₂Cl₂

With methyl-phenyl-thioether; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; 1: Hydrolysis / 2: Condensation;
DOI:10.1080/07328319908044779