(5S)-2-(4-((3-isopropyl-2-phenyloxazolidin)-5-methoxy)phenyl)-4-ethanol

Base Information

• Chemical Name: (5S)-2-(4-((3-isopropyl-2-phenyloxazolidin)-5-methoxy)phenyl)-4-ethanol
• CAS No.: 947340-61-6
• Molecular Formula: C₂₁H₂₇NO₃
• Molecular Weight: 341.45
• Mol file: 947340-61-6.mol

Synonyms:

Chemical Property of (5S)-2-(4-((3-isopropyl-2-phenyloxazolidin)-5-methoxy)phenyl)-4-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5S)-2-(4-((3-isopropyl-2-phenyloxazolidin)-5-methoxy)phenyl)-4-ethanol

There total 8 articles about (5S)-2-(4-((3-isopropyl-2-phenyloxazolidin)-5-methoxy)phenyl)-4-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(-)-O-Demethylmetoprolol (131564-69-7,62572-94-5) + benzonitrile (100-47-0) → (5S)-2-(4-((3-isopropyl-2-phenyloxazolidin)-5-methoxy)phenyl)-4-ethanol (947340-61-6)

Guidance literature:

at 150 ℃; for 20h; Acidic conditions;

Reference yield:

p-hydroxyphenethyl alcohol (501-94-0) → (5S)-2-(4-((3-isopropyl-2-phenyloxazolidin)-5-methoxy)phenyl)-4-ethanol (947340-61-6)

Guidance literature:

Multi-step reaction with 6 steps

1: potassium carbonate / acetonitrile / 6 h / Reflux

2: methanol / 7 h / 20 °C

3: pyridine; triethylamine / 20 °C

4: Rhodotorula mucilaginosa DQ₈₃₂₁₉₈ / 12 h / 28 °C / pH 6 / Microbiological reaction; phosphate-citric acid buffer

5: sodium hydroxide / methanol / 20 °C

6: toluene-4-sulfonic acid / toluene / Reflux

With pyridine; potassium carbonate; toluene-4-sulfonic acid; triethylamine; sodium hydroxide; In methanol; toluene; acetonitrile;

DOI:10.1080/00397911.2010.505699

Reference yield:

C20H29NO6 (959279-50-6) → (5S)-2-(4-((3-isopropyl-2-phenyloxazolidin)-5-methoxy)phenyl)-4-ethanol (947340-61-6)

Guidance literature:

Multi-step reaction with 3 steps

1: Rhodotorula mucilaginosa DQ₈₃₂₁₉₈ / 12 h / 28 °C / pH 6 / Microbiological reaction; phosphate-citric acid buffer

2: sodium hydroxide / methanol / 20 °C

3: toluene-4-sulfonic acid / toluene / Reflux

With toluene-4-sulfonic acid; sodium hydroxide; In methanol; toluene;

DOI:10.1080/00397911.2010.505699

upstream raw materials:

C₂₀H₂₉NO₆

C₁₈H₂₇NO₅

(-)-O-Demethylmetoprolol

benzaldehyde

Downstream raw materials:

(-)-Betaxolol