1-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridine

Base Information

• Chemical Name: 1-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridine
• CAS No.: 418795-27-4
• Molecular Formula: C₁₀H₁₂N₂O
• Molecular Weight: 176.218
• Mol file: 418795-27-4.mol

Synonyms:

Chemical Property of 1-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridine

Chemical Property:

Purity/Quality:

1-(2-methoxyethyl)-1H-Pyrrolo[2,3-b]pyridine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridine

There total 3 articles about 1-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

7-Azaindole (271-63-6) → 1-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridine (418795-27-4)

Guidance literature:

7-Azaindole; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

2-methoxyethyl halide; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

DOI:10.1248/cpb.55.255

Reference yield: 81.0%

7-Azaindole (271-63-6) + 2-Bromoethyl methyl ether (6482-24-2) → 1-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridine (418795-27-4)

Guidance literature:

7-Azaindole; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.5h;

2-Bromoethyl methyl ether; In N,N-dimethyl-formamide; mineral oil; at 60 ℃; for 24h;

DOI:10.1016/j.ejmech.2017.06.052

Reference yield:

2-methoxy-ethanol (109-86-4,95507-80-5) + 1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine (143141-23-5) → 1-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridine (418795-27-4)

Guidance literature:

With tetrabutylammomium bromide; caesium carbonate; In toluene; at 20 ℃; Inert atmosphere; Reflux;

DOI:10.1055/S-0029-1218627

upstream raw materials:

7-Azaindole

2-methoxy-ethanol

1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine

2-Bromoethyl methyl ether