5'-(N-ethylbenzhydrylamino)-2',5'-dideoxyuridine

Base Information

• Chemical Name: 5'-(N-ethylbenzhydrylamino)-2',5'-dideoxyuridine
• CAS No.: 1340593-31-8
• Molecular Formula: C₂₄H₂₇N₃O₄
• Molecular Weight: 421.496
• Mol file: 1340593-31-8.mol

Synonyms:

Chemical Property of 5'-(N-ethylbenzhydrylamino)-2',5'-dideoxyuridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-(N-ethylbenzhydrylamino)-2',5'-dideoxyuridine

There total 3 articles about 5'-(N-ethylbenzhydrylamino)-2',5'-dideoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-deoxyuridine (951-78-0,63844-76-8) → 5'-(N-ethylbenzhydrylamino)-2',5'-dideoxyuridine (1340593-31-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 20 °C / Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide / 120 - 140 °C / Inert atmosphere

With pyridine; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201100255

Reference yield:

benzophenone (119-61-9) → 5'-(N-ethylbenzhydrylamino)-2',5'-dideoxyuridine (1340593-31-8)

Guidance literature:

Multi-step reaction with 3 steps

1: titanium tetrachloride / tetrahydrofuran; dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2: methanol; sodium cyanoborohydride / tetrahydrofuran; dichloromethane / 1 h / 20 °C / Inert atmosphere

3: triethylamine / N,N-dimethyl-formamide / 120 - 140 °C / Inert atmosphere

With methanol; titanium tetrachloride; sodium cyanoborohydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201100255

Reference yield:

N-Diphenylmethylen(ethyl)amin (27126-11-0) → 5'-(N-ethylbenzhydrylamino)-2',5'-dideoxyuridine (1340593-31-8)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; sodium cyanoborohydride / tetrahydrofuran; dichloromethane / 1 h / 20 °C / Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide / 120 - 140 °C / Inert atmosphere

With methanol; sodium cyanoborohydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201100255

upstream raw materials:

benzophenone

N-Diphenylmethylen(ethyl)amin

2'-deoxyuridine