4,4-difluoro-8-(4-((2-(4-(diphenylphosphino)benzamido)ethyl)carbamoyl)phenyl)-1,3,5,7-tetramethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene

Base Information

Chemical Name:4,4-difluoro-8-(4-((2-(4-(diphenylphosphino)benzamido)ethyl)carbamoyl)phenyl)-1,3,5,7-tetramethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene
CAS No.:1429426-48-1
Molecular Formula:C₄₅H₄₆BF₂N₄O₂P
Molecular Weight:754.667
Hs Code.:

4,4-difluoro-8-(4-((2-(4-(diphenylphosphino)benzamido)ethyl)carbamoyl)phenyl)-1,3,5,7-tetramethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene

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Chemical Property of 4,4-difluoro-8-(4-((2-(4-(diphenylphosphino)benzamido)ethyl)carbamoyl)phenyl)-1,3,5,7-tetramethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene

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Technology Process of 4,4-difluoro-8-(4-((2-(4-(diphenylphosphino)benzamido)ethyl)carbamoyl)phenyl)-1,3,5,7-tetramethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene

There total 7 articles about 4,4-difluoro-8-(4-((2-(4-(diphenylphosphino)benzamido)ethyl)carbamoyl)phenyl)-1,3,5,7-tetramethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1194506-14-3
succinimid-N-yl 4-(diphenylphosphino)benzoate

: 1375105-10-4
4,4-difluoro-8-(4-((2-aminoethyl)carbamoyl)phenyl)-1,3,5,7-tetramethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene

: 1429426-48-1
4,4-difluoro-8-(4-((2-(4-(diphenylphosphino)benzamido)ethyl)carbamoyl)phenyl)-1,3,5,7-tetramethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene

Guidance literature:: With triethylamine; In chloroform; for 19h; Inert atmosphere; Reflux;
DOI:10.1039/c2dt32055j

Reference yield:

: 1033273-62-9
4,4-difluoro-8-(4-carboxyphenyl)-1,3,5,7-tetramethyl-2,6-diethyl-4-boron-3a,4a-diaza-s-indacene

: C₂₃H₂₂NO₂P

: 107-15-3,85404-18-8
ethylenediamine

: 1429426-48-1
4,4-difluoro-8-(4-((2-(4-(diphenylphosphino)benzamido)ethyl)carbamoyl)phenyl)-1,3,5,7-tetramethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene

Guidance literature:: 4,4-difluoro-8-(4-carboxyphenyl)-1,3,5,7-tetramethyl-2,6-diethyl-4-boron-3a,4a-diaza-s-indacene; With dmap; 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

ethylenediamine; In dichloromethane; at 20 ℃;

C₂₃H₂₂NO₂P; In chloroform; at 60 ℃;
DOI:10.1021/acs.inorgchem.1c02929

Reference yield:

: 619-58-9
4-iodobenzoic acid

: 1429426-48-1
4,4-difluoro-8-(4-((2-(4-(diphenylphosphino)benzamido)ethyl)carbamoyl)phenyl)-1,3,5,7-tetramethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; triethylamine / acetonitrile / 72 h / Inert atmosphere; Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C / Inert atmosphere

3: triethylamine / chloroform / 19 h / Inert atmosphere; Reflux

With palladium diacetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; chloroform; acetonitrile;
DOI:10.1039/c2dt32055j