1-(2-chlorophenyl)-6-methoxy-3-methyl-8-morpholin-4-ylimidazo[5,1-c][1,2,4]benzotriazine

Base Information

• Chemical Name: 1-(2-chlorophenyl)-6-methoxy-3-methyl-8-morpholin-4-ylimidazo[5,1-c][1,2,4]benzotriazine
• CAS No.: 1226803-23-1
• Molecular Formula: C₂₁H₂₀ClN₅O₂
• Molecular Weight: 409.875
• Mol file: 1226803-23-1.mol

Synonyms:

Chemical Property of 1-(2-chlorophenyl)-6-methoxy-3-methyl-8-morpholin-4-ylimidazo[5,1-c][1,2,4]benzotriazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-chlorophenyl)-6-methoxy-3-methyl-8-morpholin-4-ylimidazo[5,1-c][1,2,4]benzotriazine

There total 7 articles about 1-(2-chlorophenyl)-6-methoxy-3-methyl-8-morpholin-4-ylimidazo[5,1-c][1,2,4]benzotriazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3,5-trifluoro-2-nitrobenzene (315-14-0) → 1-(2-chlorophenyl)-6-methoxy-3-methyl-8-morpholin-4-ylimidazo[5,1-c][1,2,4]benzotriazine (1226803-23-1)

Guidance literature:

Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: potassium carbonate / N,N-dimethyl-formamide

3: potassium hydroxide

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾

5: palladium on activated charcoal; ammonium formate / methanol

6: acetic acid; sodium nitrite

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; ammonium formate; potassium carbonate; acetic acid; potassium hydroxide; sodium nitrite; In methanol; N,N-dimethyl-formamide; 4: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2012.07.076

Reference yield:

4-(3',5'-difluoro-4'-nitrophenyl)morpholine (864539-99-1) → 1-(2-chlorophenyl)-6-methoxy-3-methyl-8-morpholin-4-ylimidazo[5,1-c][1,2,4]benzotriazine (1226803-23-1)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: potassium hydroxide

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾

4: palladium on activated charcoal; ammonium formate / methanol

5: acetic acid; sodium nitrite

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; ammonium formate; potassium carbonate; acetic acid; potassium hydroxide; sodium nitrite; In methanol; N,N-dimethyl-formamide; 3: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2012.07.076

Reference yield:

C14H14BrFN4O3 (1400898-83-0) → 1-(2-chlorophenyl)-6-methoxy-3-methyl-8-morpholin-4-ylimidazo[5,1-c][1,2,4]benzotriazine (1226803-23-1)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium hydroxide

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾

3: palladium on activated charcoal; ammonium formate / methanol

4: acetic acid; sodium nitrite

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; ammonium formate; acetic acid; potassium hydroxide; sodium nitrite; In methanol; 2: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2012.07.076

upstream raw materials:

1,3,5-trifluoro-2-nitrobenzene

4-(3',5'-difluoro-4'-nitrophenyl)morpholine

C₁₄H₁₄BrFN₄O₃

C₁₅H₁₇BrN₄O₄