RET Kinase inhibitor 1

Base Information

Chemical Name:RET Kinase inhibitor 1
CAS No.:1627856-64-7
Molecular Formula:C₂₂H₂₁F₄N₃O₄
Molecular Weight:467.42
Hs Code.:
Mol file:1627856-64-7.mol

Synonyms:

Suppliers and Price of RET Kinase inhibitor 1

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
GSK3179106 >98%
1 g
$ 3200.00

DC Chemicals
GSK3179106 >98%
250 mg
$ 1700.00

DC Chemicals
GSK3179106 >98%
100 mg
$ 950.00

ChemScene
GSK3179106 99.40%
50mg
$ 800.00

ChemScene
GSK3179106 99.40%
10mg
$ 200.00

ChemScene
GSK3179106 99.40%
5mg
$ 110.00

ChemScene
GSK3179106 99.40%
1mg
$ 50.00

ChemScene
GSK3179106 99.40%
100mg
$ 1450.00

Cayman Chemical
RET Kinase Inhibitor 1
5mg
$ 113.00

Cayman Chemical
RET Kinase Inhibitor 1
1mg
$ 25.00

Total 12 raw suppliers

Chemical Property of RET Kinase inhibitor 1

Chemical Property:

Boiling Point:670.1±55.0 °C(Predicted)
PKA:10.30±0.10(Predicted)
Density:1.37±0.1 g/cm3(Predicted)
Storage Temp.:2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

GSK3179106 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description GSK3179106 is an inhibitor of rearranged during transfection (RET) kinase (IC50 = 0.4 nM). It is selective for RET kinase over VEGF receptor 2 (VEGFR2/KDR; IC50 = 109 nM). GSK3179106 reduces the number of abdominal contractions induced by colorectal distension in acetic acid-sensitized rats when administered at a dose of 10 mg/kg twice per day.

Technology Process of RET Kinase inhibitor 1

There total 14 articles about RET Kinase inhibitor 1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 2-(4-(4-ethoxy-6-((4-methoxybenzyl)oxy)pyridin-3-yl)-2-fluorophenyl)-N-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)i soxazol-3-yl)acetamide

: 1627856-64-7
2-(4-(4-ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fluorophenyl)-N-(5-(1,1,1- trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)acetamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 2h;

Reference yield:

: 76283-09-5
4-bromo-2-fluorobenzyl bromide

: 1627856-64-7
2-(4-(4-ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fluorophenyl)-N-(5-(1,1,1- trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: ethanol / 12 h / 60 °C / Inert atmosphere

2: sodium hydroxide; methanol / 12 h / 100 °C

3: sulfuric acid / Reflux

4: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / Inert atmosphere; Reflux

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 2 h / Inert atmosphere; Reflux

6: lithium hydroxide monohydrate; water / tetrahydrofuran / 10 h / 60 °C

7: pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / 1 h / 25 °C

8: trifluoroacetic acid / dichloromethane / 2 h / 25 °C

With pyridine; methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; sulfuric acid; water; potassium acetate; caesium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 23056-36-2
2-chloro-4-nitropyridine

: 1627856-64-7
2-(4-(4-ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fluorophenyl)-N-(5-(1,1,1- trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / 10 h / 25 °C

2: sulfuric acid; N-Bromosuccinimide / 10 h / 60 °C

3: potassium hydroxide; 18-crown-6 ether / toluene / 2 h / 120 °C

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 2 h / Inert atmosphere; Reflux

5: lithium hydroxide monohydrate; water / tetrahydrofuran / 10 h / 60 °C

6: pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / 1 h / 25 °C

7: trifluoroacetic acid / dichloromethane / 2 h / 25 °C

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; 18-crown-6 ether; lithium hydroxide monohydrate; sulfuric acid; water; caesium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;