Nadolol EP Impurity G

Base Information

• Chemical Name: Nadolol EP Impurity G
• CAS No.: 33841-03-1
• Molecular Formula: C₁₇H₂₇NO₂
• Molecular Weight: 277.407
• UNII: ZZ282S5RPN
• Mol file: 33841-03-1.mol

Synonyms:Nadolol EP Impurity G;33841-03-1;Dideoxy nadolol;ZZ282S5RPN;1-(tert-butylamino)-3-(5,6,7,8-tetrahydronaphthalen-1-yloxy)propan-2-ol;UNII-ZZ282S5RPN;2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((5,6,7,8-tetrahydro-1-naphthalenyl)oxy)-;De(2,3-dihydroxy) Nadolol;SCHEMBL11233727;ZTYWAQSTDRZAAS-UHFFFAOYSA-N;1-(5,6,7,8-tetrahydro-alpha-naphthoxy)-3-(tert.-butylamino)-2-propanol

Chemical Property of Nadolol EP Impurity G

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 277.204179104
• Heavy Atom Count: 20
• Complexity: 287

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

De(2,3-dihydroxy)Nadolol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C)NCC(COC1=CC=CC2=C1CCCC2)O
• Uses: De(2,3-dihydroxy) Nadolol is an impurity of Nadolol (N201050), a β-Adrenergic blocker, antihypertensive and antianginal.

Technology Process of Nadolol EP Impurity G

There total 2 articles about Nadolol EP Impurity G which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5,6,7,8-Tetrahydronaphthalen-1-ol (529-35-1) + tert-butylamine (75-64-9) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 1-(5,6,7,8-Tetrahydro-α-naphthoxy)-3-(tert.-butylamino)-2-propanol (33841-03-1)

Guidance literature:

Multistep reaction; (i) aq. NaOH, EtOH, (ii) /BRN= 605267/;

DOI:10.1021/jm00298a024

Reference yield:

→ 1-(5,6,7,8-Tetrahydro-α-naphthoxy)-3-(tert.-butylamino)-2-propanol (33841-03-1)

Guidance literature:

1-(tert.-Butyl)-3-azetidinol, 1. 5,6,7,8-Tetrahydro-α-naphthol, KOH, 2. Ae., 2 N-NaOH;

upstream raw materials:

5,6,7,8-Tetrahydronaphthalen-1-ol

tert-butylamine

epichlorohydrin