1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-([1,3,2]dioxaphosphocan-2-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Base Information

• Chemical Name: 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-([1,3,2]dioxaphosphocan-2-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione
• CAS No.: 327178-63-2
• Molecular Formula: C₃₆H₄₁N₂O₉P
• Molecular Weight: 676.703

Synonyms:

Chemical Property of 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-([1,3,2]dioxaphosphocan-2-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Chemical Property:

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Technology Process of 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-([1,3,2]dioxaphosphocan-2-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

There total 2 articles about 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-([1,3,2]dioxaphosphocan-2-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate (3868-27-7) → 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-([1,3,2]dioxaphosphocan-2-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione (327178-63-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 0.08 h

2: pyridine / 0.08 h

In pyridine;

DOI:10.1080/15257770008045441

Reference yield:

1 ,5-pentanediol (111-29-5) + C41H49N2O11P (130288-86-7) → 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-([1,3,2]dioxaphosphocan-2-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione (327178-63-2)

Guidance literature:

In pyridine; for 0.0833333h;

DOI:10.1080/15257770008045441

Reference yield:

1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-([1,3,2]dioxaphosphocan-2-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione (327178-63-2) → [5'-O-(4,4'-dimethoxytrityl)-thymidin-3'-yloxy]-2-oxo-1,3,2-dioxaphosphocane

Guidance literature:

With water; iodine; In pyridine; for 0.25h;

DOI:10.1080/15257770008045441

upstream raw materials:

1 ,5-pentanediol

C₄₁H₄₉N₂O₁₁P

triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate

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