[(2R,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-hydroxy-oxophosphanium;N,N-diethylethanamine

Base Information

Chemical Name:[(2R,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-hydroxy-oxophosphanium;N,N-diethylethanamine
CAS No.:3868-27-7
Molecular Formula:C31H33N2O9P.C6H15N
Molecular Weight:709.777
Hs Code.:
European Community (EC) Number:636-785-7

[(2R,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-hydroxy-oxophosphanium;N,N-diethylethanamine

Synonyms:3868-27-7;Triethylamine (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl phosphonate

Suppliers and Price of [(2R,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-hydroxy-oxophosphanium;N,N-diethylethanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [(2R,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-hydroxy-oxophosphanium;N,N-diethylethanamine

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:14
Exact Mass:708.30499208
Heavy Atom Count:50
Complexity:1020

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CC)CC.CC1=CN(C(=O)NC1=O)C2CC(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O[P+](=O)O
Isomeric SMILES:CCN(CC)CC.CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O[P+](=O)O

Technology Process of [(2R,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-hydroxy-oxophosphanium;N,N-diethylethanamine

There total 5 articles about [(2R,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-hydroxy-oxophosphanium;N,N-diethylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

: 121-44-8
triethylamine

: Ammonium 4-methylphenyl H-phosphonate

: 185738-33-4
2'-Deoxy-6-O-(2,5-dichlorophenyl)-5'-O-(4,4'-dimethoxytrityl)-2-N-isobutyrylguanosine

: 3868-27-7
triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate

Guidance literature:: triethylamine; Ammonium 4-methylphenyl H-phosphonate; With pyridine;

2'-Deoxy-6-O-(2,5-dichlorophenyl)-5'-O-(4,4'-dimethoxytrityl)-2-N-isobutyrylguanosine; With pyridine; pivaloyl chloride; at -35 ℃; for 0.5h;

Reference yield: 84.0%

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 121-44-8
triethylamine

: 3868-27-7
triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate

Guidance literature:: 5'-O-(4-4'-dimethoxytrityl)thymidine; With pyridine; diphenyl hydrogen phosphite; at 20 ℃; for 0.333333h;

triethylamine; In water; at 20 ℃;
DOI:10.1055/s-2004-815939

Reference yield: 77.0%

: 5381-99-7
2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 121-44-8
triethylamine

: 3868-27-7
triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate

Guidance literature:: 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one; 5'-O-(4-4'-dimethoxytrityl)thymidine; With pyridine; In 1,4-dioxane; at 20 ℃; for 0.333333h; Inert atmosphere;

triethylamine; With water; In 1,4-dioxane; dichloromethane; Inert atmosphere;
DOI:10.1080/15257770.2011.597366