4-chloro-2,3-difluorobenzaldehyde

Base Information

• Chemical Name: 4-chloro-2,3-difluorobenzaldehyde
• CAS No.: 1160573-23-8
• Molecular Formula: C₇H₃ClF₂O
• Molecular Weight: 176.55
• Hs Code.: 2913000090
• Mol file: 1160573-23-8.mol

Synonyms:

Chemical Property of 4-chloro-2,3-difluorobenzaldehyde

Chemical Property:

• Boiling Point: 215.2±35.0 °C(Predicted)
• Density: 1.453±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-2,3-difluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-Chloro-2,3-difluorobenzaldehyde is a building block used in synthetic synthesis.

Technology Process of 4-chloro-2,3-difluorobenzaldehyde

There total 1 articles about 4-chloro-2,3-difluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-chloro-1,2-difluorobenzene (36556-47-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-chloro-2,3-difluorobenzaldehyde (1160573-23-8)

Guidance literature:

3-chloro-1,2-difluorobenzene; With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃; for 0.5h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at -70 ℃; for 0.5h; Inert atmosphere;

Reference yield:

4-chloro-2,3-difluorobenzaldehyde (1160573-23-8) → C16H20ClF2N3O

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine; hydroxylamine hydrochloride / dichloromethane / 16 h / 20 °C

2: N-chloro-succinimide / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 - 30 °C

3: triethylamine / methanol / 1 h / 20 °C

With N-chloro-succinimide; hydroxylamine hydrochloride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

4-chloro-2,3-difluorobenzaldehyde (1160573-23-8) → 4-chloro-2,3-difluoro-N-hydroxybenzimidoyl chloride

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; hydroxylamine hydrochloride / dichloromethane / 16 h / 20 °C

2: N-chloro-succinimide / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 - 30 °C

With N-chloro-succinimide; hydroxylamine hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

3-chloro-1,2-difluorobenzene

N,N-dimethyl-formamide

Refernces